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      Clinical outcomes after anterior cruciate ligament injury: panther symposium ACL injury clinical outcomes consensus group

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          Abstract

          Purpose

          A stringent outcome assessment is a key aspect for establishing evidence-based clinical guidelines for anterior cruciate ligament (ACL) injury treatment. The aim of this consensus statement was to establish what data should be reported when conducting an ACL outcome study, what specific outcome measurements should be used and at what follow-up time those outcomes should be assessed.

          Methods

          To establish a standardized approach to assessment of clinical outcome after ACL treatment, a consensus meeting including a multidisciplinary group of ACL experts was held at the ACL Consensus Meeting Panther Symposium, Pittsburgh, PA; USA, in June 2019. The group reached consensus on nine statements by using a modified Delphi method.

          Results

          In general, outcomes after ACL treatment can be divided into four robust categories—early adverse events, patient-reported outcomes, ACL graft failure/recurrent ligament disruption and clinical measures of knee function and structure. A comprehensive assessment following ACL treatment should aim to provide a complete overview of the treatment result, optimally including the various aspects of outcome categories. For most research questions, a minimum follow-up of 2 years with an optimal follow-up rate of 80% is necessary to achieve a comprehensive assessment. This should include clinical examination, any sustained re-injuries, validated knee-specific PROs and Health-Related Quality of Life questionnaires. In the mid- to long-term follow-up, the presence of osteoarthritis should be evaluated.

          Conclusion

          This consensus paper provides practical guidelines for how the aforementioned entities of outcomes should be reported and suggests the preferred tools for a reliable and valid assessment of outcome after ACL treatment.

          Level of evidence

          V.

          Electronic supplementary material

          The online version of this article (10.1007/s00167-020-06061-x) contains supplementary material, which is available to authorized users.

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          Most cited references100

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          The ASA's Statement onp-Values: Context, Process, and Purpose

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            Measurement of health status. Ascertaining the minimal clinically important difference.

            In recent years quality of life instruments have been featured as primary outcomes in many randomized trials. One of the challenges facing the investigator using such measures is determining the significance of any differences observed, and communicating that significance to clinicians who will be applying the trial results. We have developed an approach to elucidating the significance of changes in score in quality of life instruments by comparing them to global ratings of change. Using this approach we have established a plausible range within which the minimal clinically important difference (MCID) falls. In three studies in which instruments measuring dyspnea, fatigue, and emotional function in patients with chronic heart and lung disease were applied the MCID was represented by mean change in score of approximately 0.5 per item, when responses were presented on a seven point Likert scale. Furthermore, we have established ranges for changes in questionnaire scores that correspond to moderate and large changes in the domains of interest. This information will be useful in interpreting questionnaire scores, both in individuals and in groups of patients participating in controlled trials, and in the planning of new trials.
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              Risk of Secondary Injury in Younger Athletes After Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-analysis.

              Injury to the ipsilateral graft used for reconstruction of the anterior cruciate ligament (ACL) or a new injury to the contralateral ACL are disastrous outcomes after successful ACL reconstruction (ACLR), rehabilitation, and return to activity. Studies reporting ACL reinjury rates in younger active populations are emerging in the literature, but these data have not yet been comprehensively synthesized.
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                Author and article information

                Contributors
                eleonor.svantesson@outlook.com
                Journal
                Knee Surg Sports Traumatol Arthrosc
                Knee Surg Sports Traumatol Arthrosc
                Knee Surgery, Sports Traumatology, Arthroscopy
                Springer Berlin Heidelberg (Berlin/Heidelberg )
                0942-2056
                1433-7347
                6 August 2020
                6 August 2020
                2020
                : 28
                : 8
                : 2415-2434
                Affiliations
                [1 ]GRID grid.8761.8, ISNI 0000 0000 9919 9582, Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska Academy, , University of Gothenburg, ; Gothenburg, Sweden
                [2 ]Gothenburg Sports and Trauma Research Center, Gothenburg, Sweden
                [3 ]GRID grid.8761.8, ISNI 0000 0000 9919 9582, Department of Rehabilitation and Health, Institute of Neuroscience and Physiology, Sahlgrenska Academy, , University of Gothenburg, ; Gothenburg, Sweden
                [4 ]GRID grid.1018.8, ISNI 0000 0001 2342 0938, School of Allied Health, , La Trobe University, ; Melbourne, VIC Australia
                [5 ]GRID grid.1649.a, ISNI 000000009445082X, Department of Orthopaedics, , Sahlgrenska University Hospital, ; Mölndal, Sweden
                [6 ]GRID grid.15474.33, ISNI 0000 0004 0477 2438, Department of Sportorthopedics, , Klinikum rechts der Isar Technische Universitat Munchen, ; Munich, Germany
                [7 ]GRID grid.21925.3d, ISNI 0000 0004 1936 9000, UPMC Freddie Fu Sports Medicine Center, Department of Orthopaedic Surgery, , University of Pittsburgh, ; 3200 S Water St, Pittsburgh, 15203 PA USA
                [8 ]GRID grid.411024.2, ISNI 0000 0001 2175 4264, Department of Orthopaedics, , University of Maryland School of Medicine, ; Baltimore, MD USA
                [9 ]GRID grid.412004.3, ISNI 0000 0004 0478 9977, Department of Trauma Surgery, , University Hospital Zurich, ; Zurich, Switzerland
                [10 ]GRID grid.412689.0, ISNI 0000 0001 0650 7433, Department of Orthopaedic Surgery, , University of Pittsburgh Medical Center, ; Pittsburgh, PA USA
                [11 ]GRID grid.21925.3d, ISNI 0000 0004 1936 9000, Department of Physical Therapy, , University of Pittsburgh, ; Pittsburgh, PA USA
                [12 ]GRID grid.239578.2, ISNI 0000 0001 0675 4725, Cleveland Clinic Sports Health Center, ; Garfield Heights, OH USA
                [13 ]GRID grid.266102.1, ISNI 0000 0001 2297 6811, Department of Orthopedic Surgery, , University of California, ; San Francisco, California USA
                Author information
                http://orcid.org/0000-0002-6669-5277
                Article
                6061
                10.1007/s00167-020-06061-x
                7429530
                32767052
                69fb9912-3161-4215-ace3-8f127a1b550d
                © The Author(s) 2020

                Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 22 March 2020
                : 10 May 2020
                Funding
                Funded by: Smith & Nephew
                Funded by: UPMC
                Funded by: Elizur
                Funded by: Artrex
                Funded by: Conmed
                Funded by: DJO global
                Funded by: Mid Atlantic surgical systems
                Funded by: RTI surgical
                Funded by: BlackRhino Medical
                Categories
                Knee
                Custom metadata
                © European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2020

                Surgery
                acl,anterior cruciate ligament,outcome,consensus statement,reconstruction
                Surgery
                acl, anterior cruciate ligament, outcome, consensus statement, reconstruction

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