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Abstract
Seven pure flavonoids were isolated and identified from five moss species. The flavonoids
were the flavones apigenin, apigenin-7-O-triglycoside, lucenin-2, luteolin-7-O-neohesperidoside,
saponarine and vitexin; and the biflavonoid bartramiaflavone. Some of these flavonoids
were shown to have pronounced antibacterial effects against Enterobacter cloaceae,
E. aerogenes and Pseudomonas aeruginosa (minimal bacteriostatic concentration MIC
in the range of 4-2048 micrograms/ml). Because of their antibacterial spectrum mainly
active against Gram negative bacterial strains, responsible for severe opportunistic
infections and resistant to common antibacterial therapy, these flavonoids may be
important tools in antibacterial strategies.