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Osteoarthritis: an update with relevance for clinical practice
Author(s):
Johannes WJ Bijlsma
,
Francis Berenbaum
,
Floris PJG Lafeber
Publication date
Created:
June 2011
Publication date
(Print):
June 2011
Journal:
The Lancet
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Osteoarthritis is thought to be the most prevalent chronic joint disease. The incidence of osteoarthritis is rising because of the ageing population and the epidemic of obesity. Pain and loss of function are the main clinical features that lead to treatment, including non-pharmacological, pharmacological, and surgical approaches. Clinicians recognise that the diagnosis of osteoarthritis is established late in the disease process, maybe too late to expect much help from disease-modifying drugs. Despite efforts over the past decades to develop markers of disease, still-imaging procedures and biochemical marker analyses need to be improved and possibly extended with more specific and sensitive methods to reliably describe disease processes, to diagnose the disease at an early stage, to classify patients according to their prognosis, and to follow the course of disease and treatment effectiveness. In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease. Treatment targeted more specifically at these phenotypes might lead to improved outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Author and article information
Journal
Title:
The Lancet
Abbreviated Title:
The Lancet
Publisher:
Elsevier BV
ISSN (Print):
01406736
Publication date Created:
June 2011
Publication date (Print):
June 2011
Volume
: 377
Issue
: 9783
Pages
: 2115-2126
Article
DOI:
10.1016/S0140-6736(11)60243-2
PubMed ID:
21684382
SO-VID:
6702f042-30fb-43fb-86c2-3e6bbfba775f
Copyright ©
© 2011
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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