Separation and detection of minimal length glycopeptide neoantigen epitopes centering the GSTA region of MUC1 by liquid chromatography/mass spectrometry.

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Abstract

We previously isolated antibodies binding to glycopeptide neoantigen epitopes centering the GSTA sequence of the highly glycosylated tandem repeat region of MUC1. Epitopes centering the GSTA sequence are also predicted by NetMHC programs to bind to MHC molecules. Detecting MUC1 glycopeptide epitopes remains a challenge since antigenic epitopes are often shorter than 10 amino acids.

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Journal

Journal ID (iso-abbrev): Rapid Commun Mass Spectrom

Title: Rapid communications in mass spectrometry : RCM

Publisher: Wiley

ISSN (Electronic): 1097-0231

ISSN (Print): 0951-4198

Publication date (Electronic): Mar 30 2020

Volume: 34

Issue: 6

Affiliations

[1 ] School of Medicine, Tongji University, Shanghai, 200092, China.

[2 ] School of Chemical Science and Engineering & Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai, 200092, China.

Article

DOI: 10.1002/rcm.8622

PubMed ID: 31658499

SO-VID: 66df4759-f66e-4ef5-a654-ff98b9e417af

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