Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.

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Abstract

In clinical pharmacokinetic (PK) studies, pregnant women are significantly underrepresented because of ethical and legal reasons which lead to a paucity of information on potential PK changes in this population. As a consequence, pharmacometric tools became instrumental to explore and quantify the impact of PK changes during pregnancy.

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Journal

Journal ID (iso-abbrev): Curr Pharm Des

Title: Current pharmaceutical design

Publisher: Bentham Science Publishers Ltd.

ISSN (Electronic): 1873-4286

ISSN (Print): 1381-6128

Publication date (Electronic): 2019

Volume: 25

Issue: 5

Affiliations

[1 ] Pediatric Pharmacology and Pharmacometrics Research Center, University Children's Hospital Basel (UKBB), Basel 4056, Switzerland.

[2 ] Intensive Care and Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

[3 ] Division of Clinical Pharmacology, Children's National Health System, Washington, DC, United States.

[4 ] Organ Systems, KU Leuven, Department of Development and Regeneration, Leuven, Belgium.

[5 ] Department of Pediatrics, Division of Neonatology, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands.

Article

Publisher Item ID: CPD-EPUB-97453

DOI: 10.2174/1381612825666190320135137

PubMed ID: 30894099

SO-VID: 66cc0702-3166-4ade-ab7a-a603779fefd7

History

Keywords: Pregnancy,population-pharmacokinetic modeling.,physiologically-based pharmacokinetic modeling,pharmacometrics,perinatal pharmacology,ketorolac data

Data availability:

Keywords: Pregnancy, population-pharmacokinetic modeling., physiologically-based pharmacokinetic modeling, pharmacometrics, perinatal pharmacology, ketorolac data

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