Effect of urea cream on sorafenib-associated hand-foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study.

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Abstract

Hand-foot skin reaction (HFSR) is the most common adverse event during sorafenib treatment in patients with hepatocellular carcinoma (HCC). In the present study, we aimed to investigate the role of urea cream in the prevention of HFSR or amelioration of HFSR severity.

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Journal

Journal ID (iso-abbrev): Eur J Cancer

Title: European journal of cancer (Oxford, England : 1990)

Publisher: Elsevier BV

ISSN (Electronic): 1879-0852

ISSN (Print): 0959-8049

Publication date (Electronic): November 2020

Volume: 140

Affiliations

[1 ] Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address: lys810@korea.ac.kr.

[2 ] Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.

[3 ] Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address: kjhhepar@naver.com.

[4 ] Department of Internal Medicine, Chonnam National University Medical School, South Korea. Electronic address: portalvein@naver.com.

[5 ] Yonsei Liver Center, Severance Hospital, Seoul, South Korea.

[6 ] Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju Severance Christan Hospital, South Korea.

[7 ] Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South Korea.

[8 ] Department of Internal Medicine, Pusan National University College of Medicine, Liver center, Pusan National University Yangsan Hospital, Yangsan, South Korea.

[9 ] Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, South Korea.

[10 ] Department of Internal Medicine, Yonsei University College of Medicine, South Korea.

[11 ] Department of Internal Medicine, Keimyung University School of Medicine, South Korea.

[12 ] Department of Intetnal Medicine, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, South Korea.

[13 ] Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University School of Medicine, Seoul, South Korea.

[14 ] Department of Internal Medicine, Dongnam Institute of Radiological & Medical Sciences, South Korea.

Article

Publisher Item ID: S0959-8049(20)30518-9

DOI: 10.1016/j.ejca.2020.09.012

PubMed ID: 33039810

SO-VID: 65ea4f6f-2945-4fcf-a0bb-4cf4ca0ede17

History

Keywords: Hand–foot skin reaction,Hepatocellular carcinoma,Urea cream

Data availability:

Keywords: Hand–foot skin reaction, Hepatocellular carcinoma, Urea cream

Effect of urea cream on sorafenib-associated hand-foot skin reaction in patients with hepatocellular carcinoma: A multicenter, randomised, double-blind controlled study.

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Karger: Oncology

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