The regulation of macrophage polarization by hypoxia-PADI4 coordination in Rheumatoid arthritis.

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Abstract

Hypoxia, a common feature of rheumatoid arthritis (RA), induces the over-expression of peptidyl arginine deiminase 4 (PADI4) in fibroblast-like synoviocytes (FLSs) and macrophages. However, the roles of PADI4 and its inducer hypoxia in the regulation of macrophage polarization remain unclear. This study aimed to investigate the role of hypoxia-PADI4 for macrophage polarization in RA patients.

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Author and article information

Journal

Journal ID (iso-abbrev): Int Immunopharmacol

Title: International immunopharmacology

Publisher: Elsevier BV

ISSN (Electronic): 1878-1705

ISSN (Print): 1567-5769

Publication date (Electronic): Oct 2021

Volume: 99

Affiliations

[1 ] Department of Clinical Laboratory, Shanghai East Hospital, 150 Ji Mo Road, Shanghai 200120, People's Republic of China.

[2 ] Department of Clinical Laboratory, Shanghai East Hospital, 150 Ji Mo Road, Shanghai 200120, People's Republic of China. Electronic address: billzong1318@126.com.

[3 ] Department of Clinical Laboratory, Shanghai East Hospital, 150 Ji Mo Road, Shanghai 200120, People's Republic of China. Electronic address: flieying@yeah.net.

Article

Publisher Item ID: S1567-5769(21)00624-X

DOI: 10.1016/j.intimp.2021.107988

PubMed ID: 34333356

SO-VID: 6596bae6-c7c9-483f-a58d-62b4268afc26

History

Keywords: Macrophage polarization,Hypoxia,PADI4,Rheumatoid arthritis

Data availability:

Keywords: Macrophage polarization, Hypoxia, PADI4, Rheumatoid arthritis

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