Control of the SOST bone enhancer by PTH using MEF2 transcription factors.

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Abstract

Expression of the osteocyte-derived bone formation inhibitor sclerostin in adult bone requires a distant enhancer. We show that MEF2 transcription factors control this enhancer and mediate inhibition of sclerostin expression by PTH.

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Author and article information

Journal

Journal ID (iso-abbrev): J Bone Miner Res

Title: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Publisher: Wiley

ISSN: 0884-0431

ISSN (Print): 0884-0431

Publication date (Electronic): Dec 2007

Volume: 22

Issue: 12

Affiliations

[1 ] Bone and Cartilage Unit, Musculoskeletal Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Article

Mid ID: NIHMS205830

DOI: 10.1359/jbmr.070804

PMC ID: 2882185

PubMed ID: 17696759

SO-VID: 6565658f-0128-4bb1-9d56-d881b29ea96c

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