Two New Acylated Flavonol Glycosides from the Seeds of Lepidium sativum

Abstract

Two new acylated flavonol glycosides named kaempferol-3- O-(2- O-sinapoyl)-β- d-galactopyranosyl-(1→2)-β- d-glucopyranoside-7- O-α- l-rhamnopyranoside ( 1) and quercetin-3- O-(6- O-benzoyl)-β- d-glucopyranosyl-(1→3)-β- d-galactopyranoside-7- O-α- l-rhamnopyranoside ( 2), were isolated together with six known compounds from the seeds of L. sativum. Their structures were elucidated on the basis of spectroscopic analysis and chemical methods. In vitro 1 and 2 inhibited nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC ₅₀ values of 25.36 and 25.08 µM, respectively.