Skin autofluorescence as a measure of advanced glycation end products deposition predicts 5-year amputation in patients with peripheral artery disease.

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Abstract

Patients with peripheral artery disease are at risk for critical limb ischemia and amputation. Accumulation of advanced glycation end products is increased and predictive for coronary and cerebrovascular events in several high cardiovascular risk groups. We hypothesized that accumulation of tissue advanced glycation end products, measured by skin autofluorescence (SAF), predicts amputation in patients with peripheral artery disease.

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Author and article information

Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Jun 2015

Volume: 35

Issue: 6

Affiliations

[1 ] From the Department of Internal Medicine, Division of Vascular Medicine (L.C.d.V., J.B., D.J.M., A.J.S., J.D.L.) and Department of Surgery, Division of Vascular Surgery (C.J.Z.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

[2 ] From the Department of Internal Medicine, Division of Vascular Medicine (L.C.d.V., J.B., D.J.M., A.J.S., J.D.L.) and Department of Surgery, Division of Vascular Surgery (C.J.Z.), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. j.d.lefrandt@umcg.nl.

Article

Publisher Item ID: ATVBAHA.115.305407

DOI: 10.1161/ATVBAHA.115.305407

PubMed ID: 25882066

SO-VID: 655191be-3e7f-4e2f-876f-65a3027aabfa

History

Keywords: peripheral artery disease,advanced glycation end products

Data availability:

Keywords: peripheral artery disease, advanced glycation end products

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