The recent coronavirus disease- 2019 (COVID-19) pandemic has led to the dramatic rise in use of personal protect equipment (PPE) among healthcare providers and the general public. Herein we discuss the various occupational dermatoses including allergic and irritant contact dermatitis, acne, seborrheic dermatitis, and rosacea related to frequent handwashing, disinfecting of surfaces, and prolonged wear of various PPE including face masks, gloves, and gowns. We provide an overview of published PPE-associated occupational dermatoses during the COVID-19 pandemic. We also discuss prevention strategies and treatment options to help patients with these complaints.