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      ANCA-associated vasculitis following ChAdOx1 nCoV19 vaccination: case-based review

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          Abstract

          For the foreseeable future, vaccines are the cornerstone in the global campaign against the Coronavirus Disease-19 (COVID-19) pandemic. As the number and fatalities due to COVID-19 decline and the lockdown anywise rescinded, we recognize an increase in the incidence of autoimmune disease post-COVID-19 vaccination. However, the causality of the most vaccine-induced side effects is debatable and, at best, limited to a temporal correlation. We herein report a case of a 51-year-old gentleman who developed Anti-Neutrophil Cytoplasmic Antibody (ANCA)-associated vasculitis (AAV) 2 week post-COVID-19 vaccination. The patient responded favorably to oral steroids and rituximab. Additionally, we conducted a case-based review of vaccine-associated AAV describing their clinical manifestations and treatment response of this emerging entity.

          Supplementary Information

          The online version contains supplementary material available at 10.1007/s00296-021-05069-x.

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          The COVID-19 Cytokine Storm; What We Know So Far

          Dina Ragab, Haitham Salah Eldin, Mohamed Taeimah … (2020)
          COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory distress syndrome (ARDS) in about 15 % of the cases. Mortality in COVID-19 patients has been linked to the presence of the so-called “cytokine storm” induced by the virus. Excessive production of proinflammatory cytokines leads to ARDS aggravation and widespread tissue damage resulting in multi-organ failure and death. Targeting cytokines during the management of COVID-19 patients could improve survival rates and reduce mortality.
          Article 0 comments Cited 787 times – based on 0 reviews     Review now
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            Targeting potential drivers of COVID-19: Neutrophil extracellular traps

            Betsy J Barnes, José Adrover, Amelia Baxter-Stoltzfus … (2020)
            In this Perspective, autopsy results and literature are presented supporting the hypothesis that neutrophil extracellular traps (NETs) may contribute to organ damage and mortality in COVID-19. If correct, existing drugs that target NETs, although unspecific, may benefit COVID-19 patients.
            Article 0 comments Cited 741 times – based on 0 reviews     Review now
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              Three Doses of an mRNA Covid-19 Vaccine in Solid-Organ Transplant Recipients

              Nassim Kamar, Florence Abravanel, Olivier Marion … (2021)
              Article 0 comments Cited 448 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Raja Ramachandran:
                ORCID: http://orcid.org/0000-0002-1273-9107
                drraja1980@gmail.com
                Journal
                Journal ID (nlm-ta): Rheumatol Int
                Journal ID (iso-abbrev): Rheumatol Int
                Title: Rheumatology International
                Publisher: Springer Berlin Heidelberg (Berlin/Heidelberg )
                ISSN (Print): 0172-8172
                ISSN (Electronic): 1437-160X
                Publication date (Electronic): 5 February 2022
                Pages: 1-10
                Affiliations
                [1 ]GRID grid.415131.3, ISNI 0000 0004 1767 2903, Department of Nephology, , Postgraduate Institute of Medical Education and Research, ; Chandigarh, India
                [2 ]GRID grid.415131.3, ISNI 0000 0004 1767 2903, Department of Internal Medicine, , Postgraduate Institute of Medical Education and Research, ; Chandigarh, India
                [3 ]GRID grid.415131.3, ISNI 0000 0004 1767 2903, Department of Histopathology, , Postgraduate Institute of Medical Education and Research, ; Chandigarh, India
                [4 ]Dr Lal Pathlabs, New Delhi, India
                [5 ]GRID grid.414489.4, ISNI 0000 0004 1768 2079, Department of Nephrology, , IGMC, ; Shimla, India
                Author information
                http://orcid.org/0000-0001-8722-6413
                http://orcid.org/0000-0002-9727-044X
                http://orcid.org/0000-0001-5876-9232
                http://orcid.org/0000-0003-0196-3442
                http://orcid.org/0000-0003-0813-1243
                http://orcid.org/0000-0002-8955-1428
                http://orcid.org/0000-0002-2642-8895
                http://orcid.org/0000-0003-4806-2297
                http://orcid.org/0000-0002-1273-9107
                Article
                Publisher ID: 5069
                DOI: 10.1007/s00296-021-05069-x
                PMC ID: 8817770
                PubMed ID: 35124725
                SO-VID: 65111f9a-ca9b-4478-867f-93a473fab81f
                Copyright © © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022
                License:

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                History
                Date received : 18 October 2021
                Date accepted : 11 December 2021
                Categories
                Subject: Case Based Review

                ScienceOpen disciplines: Rheumatology
                Keywords: covid-19 vaccine,sars-cov-2 vaccine,anca-associated vasculitis,auto-immunity,glomerulonephritis
                Data availability:
                ScienceOpen disciplines: Rheumatology
                Keywords: covid-19 vaccine, sars-cov-2 vaccine, anca-associated vasculitis, auto-immunity, glomerulonephritis

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