For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
4
views
139
references
 Top references
cited by
7
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      503
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      MicroRNAs, Multiple Sclerosis, and Depression

      review-article
      Author(s):
      Editor(s):
      Publication date (Electronic):
      Journal: International Journal of Molecular Sciences
      Publisher: MDPI
      Keywords: biomarker, depression, microRNA, multiple sclerosis, treatment

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord. There are several disease courses in MS including relapsing–remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS). Up to 50% of MS patients experience depressive disorders. Major depression (MD) is a serious comorbidity of MS. Many dysfunctions including neuroinflammation, peripheral inflammation, gut dysbiosis, chronic oxidative and nitrosative stress, and neuroendocrine and mitochondrial abnormalities may contribute to the comorbidity between MS and MD. In addition to these actions, medical treatment and microRNA (miRNA) regulation may also be involved in the mechanisms of the comorbidity between MS and MD. In the study, I review many common miRNA biomarkers for both diseases. These common miRNA biomarkers may help further explore the association between MS and MD.

          Related collections

          Most cited references139

          • Record: found
          • Abstract: found
          • Article: not found

          Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

          Benjamin Lewis, Christopher Burge, David Bartel (2005)
          We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed (nucleotides 2-7) of the miRNA. An overrepresentation of conserved adenosines flanking the seed complementary sites in mRNAs indicates that primary sequence determinants can supplement base pairing to specify miRNA target recognition. In a four-genome analysis of 3' UTRs, approximately 13,000 regulatory relationships were detected above the estimate of false-positive predictions, thereby implicating as miRNA targets more than 5300 human genes, which represented 30% of our gene set. Targeting was also detected in open reading frames. In sum, well over one third of human genes appear to be conserved miRNA targets.
          Article 0 comments Cited 940 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies.

            Floriana Luppino, Leonore de Wit, Paul Bouvy … (2010)
            Association between obesity and depression has repeatedly been established. For treatment and prevention purposes, it is important to acquire more insight into their longitudinal interaction. To conduct a systematic review and meta-analysis on the longitudinal relationship between depression, overweight, and obesity and to identify possible influencing factors. Studies were found using PubMed, PsycINFO, and EMBASE databases and selected on several criteria. Studies examining the longitudinal bidirectional relation between depression and overweight (body mass index 25-29.99) or obesity (body mass index > or =30) were selected. Unadjusted and adjusted odds ratios (ORs) were extracted or provided by the authors. Overall, unadjusted ORs were calculated and subgroup analyses were performed for the 15 included studies (N = 58 745) to estimate the effect of possible moderators (sex, age, depression severity). Obesity at baseline increased the risk of onset of depression at follow-up (unadjusted OR, 1.55; 95% confidence interval [CI], 1.22-1.98; P or =60 years) but not among younger persons (aged <20 years). Baseline depression (symptoms and disorder) was not predictive of overweight over time. However, depression increased the odds for developing obesity (OR, 1.58; 95% CI, 1.33-1.87; P < .001). Subgroup analyses did not reveal specific moderators of the association. This meta-analysis confirms a reciprocal link between depression and obesity. Obesity was found to increase the risk of depression, most pronounced among Americans and for clinically diagnosed depression. In addition, depression was found to be predictive of developing obesity.
            Article 0 comments Cited 701 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              The role of MicroRNAs in human cancer

              Yong Y. Peng, Carlo Croce (2016)
              MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of gene expression. Compelling evidences have demonstrated that miRNA expression is dysregulated in human cancer through various mechanisms, including amplification or deletion of miRNA genes, abnormal transcriptional control of miRNAs, dysregulated epigenetic changes and defects in the miRNA biogenesis machinery. MiRNAs may function as either oncogenes or tumor suppressors under certain conditions. The dysregulated miRNAs have been shown to affect the hallmarks of cancer, including sustaining proliferative signaling, evading growth suppressors, resisting cell death, activating invasion and metastasis, and inducing angiogenesis. An increasing number of studies have identified miRNAs as potential biomarkers for human cancer diagnosis, prognosis and therapeutic targets or tools, which needs further investigation and validation. In this review, we focus on how miRNAs regulate the development of human tumors by acting as tumor suppressors or oncogenes.
              Article 0 comments Cited 674 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Damiana Pieragostino: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 21 July 2021
                Publication date Collection: August 2021
                Volume: 22
                Issue: 15
                Electronic Location Identifier: 7802
                Affiliations
                Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan; wang@ 123456stat.nctu.edu.tw
                Author information
                https://orcid.org/0000-0002-5863-0756
                Article
                Publisher ID: ijms-22-07802
                DOI: 10.3390/ijms22157802
                PMC ID: 8346048
                PubMed ID: 34360568
                SO-VID: 644186d2-aed0-4af4-b8f2-c494398eeddd
                Copyright © © 2021 by the author.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 07 June 2021
                Date accepted : 16 July 2021
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: biomarker,depression,microrna,multiple sclerosis,treatment
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: biomarker, depression, microrna, multiple sclerosis, treatment

                Comments

                Comment on this article

                scite_

                Similar content503

                See all similar

                Cited by7

                See all cited by

                Most referenced authors1,778

                See all reference authors