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Alterations in Gut Microbiome in Cirrhosis as Assessed by Quantitative Metagenomics: Relationship With Acute-on-Chronic Liver Failure and Prognosis
Cristina Solé ,
Susie Guilly ,
Kevin Da Silva ,
Marta Llopis ,
Emmanuelle Le-Chatelier ,
Patricia Huelin ,
Marta Carol ,
Rebeca Moreira ,
Núria Fabrellas ,
Gloria De Prada ,
Laura Napoleone ,
Isabel Graupera ,
Elisa Pose ,
Adrià Juanola ,
Natalia Borruel ,
Magali Berland ,
David Toapanta ,
Francesc Casellas ,
Francisco Guarner ,
Jöel Doré ,
Elsa Solà ,
Stanislav Dusko Ehrlich ,
Pere Ginès
January 2021
January 2021
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Abstract
<p class="first" id="d8994726e287">Cirrhosis is associated with changes in gut microbiome
composition. Although acute-on-chronic
liver failure (ACLF) is the most severe clinical stage of cirrhosis, there is lack
of information about gut microbiome alterations in ACLF using quantitative metagenomics.
We investigated the gut microbiome in patients with cirrhosis encompassing the whole
spectrum of disease (compensated, acutely decompensated without ACLF, and ACLF). A
group of healthy subjects was used as control subjects.
</p>