A new look at blood coagulation factor V.

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Abstract

Factor V plays an essential role in hemostasis and has a profound influence on thrombin generation. The aim of this review is to highlight recent advances in our understanding of the biology of factor V which shed light on the variable bleeding tendencies in severe factor V deficiency. Furthermore, new mechanistic insights responsible for maintaining factor V as an inactive procofactor will be discussed.

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Journal

Journal ID (iso-abbrev): Curr. Opin. Hematol.

Title: Current opinion in hematology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1531-7048

ISSN (Print): 1065-6251

Publication date (Electronic): Sep 2011

Volume: 18

Issue: 5

Affiliations

[1 ] Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA. rcamire@mail.med.upenn.edu

Article

DOI: 10.1097/MOH.0b013e3283497ebc

PubMed ID: 21730834

SO-VID: 64240ca1-3109-4bd7-9912-99b15ab927dc

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