Influence of ABCB-1, ERCC-1 and ERCC-2 gene polymorphisms on response to capecitabine and oxaliplatin (CAPOX) treatment in colorectal cancer (CRC) patients of South India.

Varma, Ashok; Mathaiyan, Jayanthi; Shewade, Deepak G.; Dubashi, Biswajit; Sunitha, Kodidela

doi:10.1111/jcpt.13166

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Influence of ABCB-1, ERCC-1 and ERCC-2 gene polymorphisms on response to capecitabine and oxaliplatin (CAPOX) treatment in colorectal cancer (CRC) patients of South India.

Author(s): Ashok Varma ¹ , Jayanthi Mathaiyan ¹ , Deepak Shewade ¹ , Biswajit Dubashi ² , Kodidela Sunitha ¹

Publication date (Electronic): Aug 2020

Journal: Journal of clinical pharmacy and therapeutics

Publisher: Wiley

Keywords: ATP-binding cassette family B member 1 (ABCB1), CAPOX regimen, P-glycoprotein, excision repair cross-complementing protein (ERCC), response variations, single nucleotide polymorphisms

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Abstract

High interindividual response variability was reported with capecitabine and oxaliplatin (CAPOX) regimen in colorectal cancer (CRC). The single nucleotide polymorphisms (SNPs) of the genes related to drug efflux transport (ABCB1) and DNA repair (ERCC) could result in altered tumour response. Hence, this study was designed to assess the influence of ABCB1, ERCC-1 and ERCC-2 gene polymorphisms on tumour response to CAPOX treatment in CRC patients of South Indian origin.

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Journal ID (iso-abbrev): J Clin Pharm Ther

Title: Journal of clinical pharmacy and therapeutics

Publisher: Wiley

ISSN (Electronic): 1365-2710

ISSN (Print): 0269-4727

Publication date (Electronic): Aug 2020

Volume: 45

Issue: 4

Affiliations

[1 ] Pharmacology Department, JIPMER, Puducherry, India.

[2 ] Regional Cancer Centre, JIPMER, Puducherry, India.

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DOI: 10.1111/jcpt.13166

PubMed ID: 32399998

SO-VID: 641ac2c0-3bcc-45f8-8998-74635a02b2c4

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Keywords: response variations,ATP-binding cassette family B member 1 (ABCB1),CAPOX regimen,P-glycoprotein,excision repair cross-complementing protein (ERCC),single nucleotide polymorphisms

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Keywords: response variations, ATP-binding cassette family B member 1 (ABCB1), CAPOX regimen, P-glycoprotein, excision repair cross-complementing protein (ERCC), single nucleotide polymorphisms

Influence of ABCB-1, ERCC-1 and ERCC-2 gene polymorphisms on response to capecitabine and oxaliplatin (CAPOX) treatment in colorectal cancer (CRC) patients of South India.

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