Influencing Factors of Serum Transforming Growth Factor-β1 in Han, Uyghur, and Kazak Patients in the Xinjiang Uygur Autonomous Region

Abstract

Objective: To investigate the influencing factors of serum transforming growth factor-β1 (TGF-β1) in Han, Uyghur, and Kazak individuals with essential hypertension in the Xinjiang Uygur Autonomous Region.

Methods: A total of 271 patients (Han, 129 cases; Uyghur, 70 cases; Kazak, 72 cases) with hypertension admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2014 to May 2016 were recruited for the study. The clinical data of the patients were collected. The correlation between serum TGF-β1 and clinical indices in the three ethnic groups were analyzed, the related factors of TGF-β1 were analyzed using multivariate linear regression.

Results: Serum TGF-β1 levels were positively correlated with systolic blood pressure, diastolic blood pressure, and heart rate in the Han patients (r=0.216, 0.236, 0.194, P<0.05) ; serum TGF-β1 level was positively correlated with creatinine, serum cystatin C, and urinary microalbumin in the Uygur patients (r=0.429, 0.446, 0.446, P<0.05), and negatively correlated with eGFR in the Uygur patients (r=-0.446, P<0.05). In the Kazak patients, serum TGF-β1 levels showed positive correlations with triglyceride and fasting blood glucose (r=0.446, 0.384, P<0.05). Multivariate linear regression analyses showed that the serum TGF-β1 level was independently associated with diastolic blood pressure (β=0.216) in Han patients, and serum cystatin C (β=0.531), eGFR (β=-0.448), and urinary microalbumin (β=0.603) in the Uygur patients. Triglyceride (β=0.469), fasting blood glucose (β=0.248), creatinine (β=0.315), and urinary sodium/urinary potassium (β=0.528), were associated with TGF-β1 levels in the Kazak patients.

Conclusion: Diastolic blood pressure was independently associated with TGF-β1 levels in Han patients; serum cystatin C, eGFR, and urinary microalbumin were independently associated with TGF-β1 levels in Uighur patients; triglyceride, fasting blood glucose, creatinine, and urinary sodium/urine potassium were independently associated with serum TGF-β1 levels in Kazak patients.