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      Uso indevido de medicamentos por pessoas com lesão medular: uma revisão integrativa Translated title: Misuse of medication by people with spinal cord injury: an integrative review

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          Abstract

          Resumo A Lesão Medular (LM) caracteriza-se pela falta de funcionamento total ou parcial da medula espinhal em consequência de uma lesão abrupta, ferimentos, luxações, doenças autoimunes entre outras causas. O estudo teve por objetivo investigar o uso indevido de medicamentos por pessoas com lesão medular, de acordo com a literatura. Realizou-se uma revisão integrativa, em junho de 2019, seguindo as recomendações do PRISMA. Buscaram-se estudos publicados nas bases de dados MedLine, Scopus, Bdenf, Lilacs e Web of Science por meio de dois cruzamentos realizados com os termos “Analgesics, Opioid and Spinal Cord Injuries” e “Drug Misuseand Spinal Cord Injuries”, bem como estudos encontrados nas referências dos artigos selecionados. Identificaram-se 187 artigos, sendo selecionados dez. Nove estudos foram realizados nos Estados Unidos e um no Canadá, e todos foram publicados na língua inglesa, de 2014 a 2018. O uso indevido foi constatado nas pesquisas e esteve relacionado com os seguintes fatores: dor, raça não branca, utilização frequente de opióides, tabagismo, alcoolismo, consumo de maconha, dependência, eventos adversos, depressão, lesões lombares/sacrais, faixa etária jovem, baixa escolaridade, polifarmácia, erro na prescrição, automedicação e falhas na dispensação, mesmo com prescrição por profissionais de saúde. As pessoas com LM fazem uso indevido de medicamentos, sobretudo com excesso de analgésicos.

          Translated abstract

          Abstract Spinal cord Injury (SCI) is characterized by total or partial spinal cord malfunction due to an abrupt lesion, injury, dislocation, auto-immune diseases among other things. The objective of this study was to investigate the improper use of medications bypersons with spinal cord injury, according to the literature. A literature review was conducted, in June 2019, following the recommendations of PRISMA. Sought studies published in Medline, Scopus, Bdenf, Lilacs and Web of Science databases by crossing the terms “Analgesics, Opioid and Spinal Cord Injuries” and “Drug Misuse and Spinal Cord Injuries”, and studies found in references of the selected articles. Had been identified 187 articles, and selected ten. Nine studies were performed in USA and one in Canadá and all researches selected had been performed in USA and published in English, between 2014 and 2018. Misuse was found in research and was related to the following factors: pain, black race, frequent use of opioids, smoking, alcoholism, cannabis use, addiction, adverse events, depression, lumbar/sacral injury, young age group, low education, polypharmacy, prescription errors, self-medication and dispensation failures, even with prescription by health professionals. People with SCI make misuse of medicines, especially with excess painkillers.

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          Revisão integrati va: o que é e como fazer

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            The current role of steroids in acute spinal cord injury.

            Acute spinal cord injury (ASCI) is a catastrophic event that can profoundly affect the trajectory of a patient's life. Debate continues over the pharmacologic management of ASCI, specifically, the widespread but controversial use of the steroid methylprednisolone (MP). Treatment efforts are impeded because of limitations in understanding of the pathobiology of ASCI and the difficulty in proving the efficacy of therapies. This review presents the pathophysiology of ASCI and the laboratory and clinical findings on the use of MP. The use of MP remains a contentious issue in part because of the catastrophic nature of ASCI, the paucity of treatment options, and the legal ramifications. Although historical data on the use of MP in ASCI have been challenged, more recent studies have been used both to support and to oppose treatment of ASCI with steroids. ASCI is a devastating event with a complex aftermath of secondary damaging processes that worsen the initial injury. Although the results of NASCIS (National Acute Spinal Cord Injury Study) II and III trials led to the widespread adoption of a high-dose MP regimen for patients treated within 8 hours of injury, subsequent studies have called into question the validity of NASCIS conclusions. Further evidence of the ineffectiveness of the MP protocol has led to declining confidence in the treatment over the last decade. At the present time, high-dose MP cannot be recommended as a standard of care, but it remains an option until supplanted by future evidence-based therapies. Copyright © 2014 Elsevier Inc. All rights reserved.
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              Predictors of Prescription Opioid Use 4 Months After Traumatic Musculoskeletal Injury and Corrective Surgery: A Prospective Study

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                Author and article information

                Journal
                psd
                Psicologia, Saúde & Doenças
                Psic., Saúde & Doenças
                Sociedade Portuguesa de Psicologia da Saúde (Lisboa, , Portugal )
                1645-0086
                December 2020
                : 21
                : 3
                : 935-943
                Affiliations
                [1] Paraíba orgnameUniversidade Estadual da Paraíba orgdiv1Universidade de Pernambuco orgdiv2Programa Associado de Pós-graduação em Enfermagem Brazil jessykachavessilva@ 123456gmail.com
                Article
                S1645-00862020000300935 S1645-0086(20)02100300935
                10.15309/20psd210332
                63eebfa6-d4b1-41f0-a56c-0ffad4e82313

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 12 November 2020
                : 17 October 2019
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 19, Pages: 9
                Product

                SciELO Portugal

                Categories
                Artigo

                spinal cord injuries,drug misuse,Analgésicos,opióides,traumatismos da medula espinal,uso indevido de medicamentos,Analgesics,opioid

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