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Ketamine enhances visual sensory evoked potential LTP in patients with major depressive disorder
Rachael L. Sumner ,
Rebecca McMillan ,
Meg J. Spriggs ,
Doug Campbell ,
Gemma Malpas ,
Elizabeth Maxwell ,
Carolyn Deng ,
John Hay ,
Rhys Ponton ,
Ian J. Kirk ,
Frederick Sundram ,
Suresh D. Muthukumaraswamy
July 2019
July 2019
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Abstract
The rapid-acting clinical effects of ketamine as a novel treatment for depression
along with its complex pharmacology have made it a growing research area. One of the
key mechanistic hypotheses for how ketamine works to alleviate depression is by enhancing
long-term potentiation (LTP)-mediated neural plasticity.