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Impact of borderline-subclinical hypothyroidism on subsequent pregnancy outcome in women with unexplained recurrent pregnancy loss.
Sayaka Uchida
1 ,
Tetsuo Maruyama
1 ,
Maki Kagami
1 ,
Fumie Miki
1 ,
Hanako Hihara
1 ,
Satomi Katakura
1 ,
Yushi Yoshimasa
1 ,
Hirotaka Masuda
1 ,
Hiroshi Uchida
1 ,
Mamoru Tanaka
1
Jun 2017
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Abstract
Because subclinical hypothyroidism (thyroid-stimulating hormone [TSH] > 4.5 IU/mL) is associated with adverse pregnancy outcome, including early pregnancy loss, TSH is recommended to be titrated to ≤2.5 mIU/L in levothyroxine-treated women before pregnancy. The purpose of this study was to determine whether borderline-subclinical hypothyroidism (borderline-SCH; 2.5 < TSH ≤ 4.5 IU/mL) affects the outcome of subsequent pregnancies in women with unexplained recurrent pregnancy loss (uRPL).