Bacillus amyloliquefaciens B10 inhibits aflatoxin B1-induced cecal inflammation in mice by regulating their intestinal flora.

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Abstract

Aflatoxin B1 is a mycotoxin that widely exists in feed and has a great impact on human and animal health. This study aimed to examine whether Bacillus amyloliquefaciens B10 protected against aflatoxin B1-induced cecal inflammation in mice. It was found that Bacillus amyloliquefaciens B10 could significantly improve the effects of AFB1 on body weight and intestinal inflammation of mice and enhance the expression of tight-junction protein. Compared with the CON group, the combination of AFB1 and B10 significantly increased the abundance of Actinobacteria and Bacilli in a collaborative manner, and significantly reduced the abundance of Ruminococcae, Lactobacillaceae and Clostridia. Meanwhile, the results showed that the abundance of Bacterides and Bacterdia in AFB1 + B10 group was significantly lower than that of AFB1 group, and the Firmicutes increased significantly. Bacillus amyloliquefaciens B10 can be used as a feed additive and alleviate cecal inflammation induced by AFB1 in mice by regulating intestinal flora.

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Author and article information

Journal

Journal ID (iso-abbrev): Food Chem Toxicol

Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Publisher: Elsevier BV

ISSN (Electronic): 1873-6351

ISSN (Print): 0278-6915

Publication date (Electronic): Oct 2021

Volume: 156

Affiliations

[1 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: 2020200157@stu.syau.edu.cn.

[2 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: 2019240364@stu.syau.edu.cn.

[3 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: 2019240368@stu.syau.edu.cn.

[4 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: tianchengwang@syau.edu.cn.

[5 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: lipeng2008@syau.edu.vn.

[6 ] SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: abwu@sibs.ac.cn.

[7 ] Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic. Electronic address: eugenie.nepovimova@uhk.cz.

[8 ] College of Animal Science & Veterinary Medicine, Shenyang Agricultural University, Shenyang, 110866, China. Electronic address: longmiao@syau.edu.cn.

[9 ] MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, China; Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic. Electronic address: wuwenda@njau.edu.cn.

[10 ] Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003, Hradec Kralove, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. Electronic address: kamil.kuca@uhk.cz.

Article

Publisher Item ID: S0278-6915(21)00471-3

DOI: 10.1016/j.fct.2021.112438

PubMed ID: 34303774

SO-VID: 636ce2e2-8fae-4ee6-9fcf-2aef26397898

History

Keywords: Bacillus amyloliquefaciens B10,Intestinal flora,Aflatoxin B1,Tight junction protein

Data availability:

Keywords: Bacillus amyloliquefaciens B10, Intestinal flora, Aflatoxin B1, Tight junction protein

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