Retinal and choroidal thickness in fuchs uveitis syndrome: a contralateral eye study

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Abstract

Background

To investigate the subfoveal retinal and choroidal thickness in patients with unilateral Fuchs Uveitis Syndrome (FUS).

Methods

This comparative contralateral study was performed in affected eyes with FUS versus fellow eyes. For each eye parameters such as subfoveal choroidal thickness (SCT), subfoveal choriocapillary thickness (SCCT), central macular thickness (CMT), and central macular volume (CMV) were measured; then the measured values of affected and fellow unaffected eye were compared.

Results

Thirty-seven patients (74 eyes) including 19 females (51.4%) with a mean age of 36.9 ± 7.6 years were enrolled. The mean SCT was lower in the affected eyes (344.51 ± 91.67) than in the fellow (375.59 ± 87.33) with adjusting for duration of disease and axial lengths ( P < 0.001). The mean SCCT, CMT, and CMV were higher in eyes with FUS than in fellow eyes ( P < 0.05).

Conclusions

The result of our study demonstrated that affected eyes in patients with FUS tend to have thinner SCT and thicker SCCT and CMT compared to uninvolved fellow eyes.

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Most cited references 39

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Enhanced depth imaging spectral-domain optical coherence tomography.

Maria C Pozzoni, Hideki Koizumi, Maria Pozonni … (2008)

To describe a method to obtain images of the choroid using conventional spectral-domain (SD) optical coherence tomography (OCT) and to evaluate choroidal thickness measurements using these images. Observational case series. The images were obtained by positioning the SD OCT device close enough to the eye to obtain an inverted representation of the fundus in healthy volunteers who did not have pupillary dilation. Seven sections, each comprised of 100 averaged scans, were obtained within a 5- x 15-degree rectangle centered on the fovea. The choroidal thickness under the fovea in each image was measured by independent observers. The choroidal thickness could be evaluated in every subject's choroidal image. The mean choroidal thickness under the fovea was 318 microm in the right eye and 335 microm in the left eye. The choroidal thickness showed a high correlation in both eyes (r = 0.82; P < .001). The correlation between the measurements performed by the independent observers was highly significant (right eye, r = 0.93; left eye, r = 0.97; P < .001 for both). This method provides detailed, measurable images from the choroid, a structure that heretofore has been difficult to image in clinical practice.

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Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease.

Hiroshi Oyamada, Tomohiro Iida, Tetsuju Sekiryu … (2011)

To evaluate the subfoveal choroidal thickness in Vogt-Koyanagi-Harada (VKH) disease using enhanced depth imaging optical coherence tomography. Retrospective observational study. Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography, in which the optical coherence tomography instrument was placed close enough to the eye to obtain an inverted image, which was averaged for 100 scans. All patients were diagnosed as having the ocular findings of VKH disease with or without extraocular disorders. The patients were followed during their initial treatment with corticosteroids. All 8 patients (16 eyes) with acute phase VKH disease presented with thickening of the choroid. The serous retinal detachment disappeared in 1 month after corticosteroid treatment. The mean choroidal thickness in 16 eyes decreased from 805 ± 173 μm at the first visit to 524 ± 151 μm at 3 days (P < 0.001) and 341 ± 70 μm by 2 weeks (P < 0.001). Patients with active VKH disease have markedly thickened choroids, possibly related not only to inflammatory infiltration but also to increased exudation. Both the choroidal thickness and the exudative retinal detachment decreased quickly with corticosteroid treatment. Enhanced depth imaging optical coherence tomography can be used to evaluate the choroidal involvement in VKH disease in the acute stages and may prove useful in the diagnosis and management of this disease noninvasively.

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Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease.

Makiko Nakayama, Hiroshi Keino, Annabelle A. Okada … (2016)

Optical coherence tomography (OCT) using enhanced depth imaging (EDI) allows evaluation of choroidal thickness. Our objective was to analyze subfoveal choroidal thickness by EDI-OCT before and after the initiation of high-dose corticosteroid treatment in 8 patients (16 eyes) with new-onset acute Vogt-Koyanagi-Harada (VKH) disease. Retrospective review of clinical records. The outer border of the choroid was not evident by EDI-OCT in any patients at presentation. Subfoveal choroidal thickness was measurable by 1 week after the initiation of treatment (mean, 578 μm) and decreased thereafter (mean at 1 month, 397 μm; 3 months, 392 μm; 6 months, 384 μm; 12 months, 332 μm). Rebound of choroidal thickening was observed in three patients (five eyes) during corticosteroid tapering in the absence of other evidence of increased inflammation. Peripapillary atrophy was present at 12 months in 6 of 6 eyes that had a choroidal thickness >550 μm at 1 week after initiating treatment, in contrast to none of the 8 eyes with a choroidal thickness ≤550 μm (P = 0.0003). Enhanced depth imaging-optical coherence tomography revealed decreasing choroidal thickness with high-dose corticosteroid treatment in our patients. Choroidal thickness as measured by EDI-OCT may serve as a marker for degree of choroidal inflammation in acute VKH disease.

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Author and article information

Contributors

Mohsen Pourazizi: m.pourazizi@yahoo.com

Journal

Journal ID (nlm-ta): BMC Ophthalmol

Journal ID (iso-abbrev): BMC Ophthalmol

Title: BMC Ophthalmology

Publisher: BioMed Central (London )

ISSN (Electronic): 1471-2415

Publication date (Electronic): 12 July 2024

Publication date PMC-release: 12 July 2024

Publication date Collection: 2024

Volume: 24

Electronic Location Identifier: 283

Affiliations

[1 ]Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, ( https://ror.org/04waqzz56) Isfahan, Iran

[2 ]Social Determinants of Health Research Center, Semnan University of Medical Sciences, ( https://ror.org/05y44as61) Semnan, Iran

[3 ]Department of Epidemiology and Biostatistics, School of Medicine, Semnan University of Medical Sciences, ( https://ror.org/05y44as61) Semnan, Iran

[4 ]GRID grid.411036.1, ISNI 0000 0001 1498 685X, Student Research Committee, , Isfahan University of Medical Sciences, ; Isfahan, Iran

Article

Publisher ID: 3554

DOI: 10.1186/s12886-024-03554-y

PMC ID: 11241905

PubMed ID: 38997641

SO-VID: 633d9ba9-c1b7-4df4-8650-861a167f2d2d

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

History

Date received : 8 February 2024

Date accepted : 2 July 2024

Custom metadata

ScienceOpen disciplines: Ophthalmology & Optometry

Keywords: fuchs uveitis syndrome,fuchs heterochromic iridocyclitis,anterior uveitis,choroidal thickness,choriocapillary,central macular thickness,central macular volume

Data availability:

ScienceOpen disciplines: Ophthalmology & Optometry

Keywords: fuchs uveitis syndrome, fuchs heterochromic iridocyclitis, anterior uveitis, choroidal thickness, choriocapillary, central macular thickness, central macular volume

Retinal and choroidal thickness in fuchs uveitis syndrome: a contralateral eye study

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Abstract

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Conclusions

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Karger: Ophthalmology

Most cited references 39

Enhanced depth imaging spectral-domain optical coherence tomography.

Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease.

Enhanced depth imaging optical coherence tomography of the choroid in Vogt-Koyanagi-Harada disease.

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