MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.

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Abstract

Recent reports have identified recurrent MED12 somatic mutations in fibroadenomas and phyllodes tumours. The frequency and type of somatic mutations were noted to be similar to those of uterine leiomyomas. We aimed to investigate protein expression of MED12, correlating it to MED12 mutational status and expression of oestrogen receptors (ER).

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Author and article information

Journal

Journal ID (iso-abbrev): J Clin Pathol

Title: Journal of clinical pathology

Publisher: BMJ

ISSN (Electronic): 1472-4146

ISSN (Print): 0021-9746

Publication date (Electronic): Oct 2016

Volume: 69

Issue: 10

Affiliations

[1 ] Department of Pathology, Singapore General Hospital, Singapore Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

[2 ] Department of Medical Oncology, National Cancer Centre Singapore, Singapore.

[3 ] Department of Pathology, Singapore General Hospital, Singapore.

[4 ] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore.

[5 ] Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Article

Publisher Item ID: jclinpath-2015-203590

DOI: 10.1136/jclinpath-2015-203590

PubMed ID: 27056456

SO-VID: 62b98c10-fc0f-49f8-9097-7c2caff83b52

Copyright © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

History

Keywords: BREAST,HISTOPATHOLOGY,IMMUNOHISTOCHEMISTRY

Data availability:

Keywords: BREAST, HISTOPATHOLOGY, IMMUNOHISTOCHEMISTRY

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