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INTERLEUKIN-10AND THEINTERLEUKIN-10 RECEPTOR
Kevin W. Moore
1
,
2
,
3 ,
Rene de Waal Malefyt
1
,
2
,
3 ,
Robert L. Coffman
1
,
2
,
3 ,
Anne O'Garra
1
,
2
,
3
April 2001
April 2001
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and
effector function of T cells, monocytes, and macrophages, is a multifunctional cytokine
with diverse effects on most hemopoietic cell types. The principal routine function
of IL-10 appears to be to limit and ultimately terminate inflammatory responses. In
addition to these activities, IL-10 regulates growth and/or differentiation of B cells,
NK cells, cytotoxic and helper T cells, mast cells, granulocytes, dendritic cells,
keratinocytes, and endothelial cells. IL-10 plays a key role in differentiation and
function of a newly appreciated type of T cell, the T regulatory cell, which may figure
prominently in control of immune responses and tolerance in vivo. Uniquely among hemopoietic
cytokines, IL-10 has closely related homologs in several virus genomes, which testify
to its crucial role in regulating immune and inflammatory responses. This review highlights
findings that have advanced our understanding of IL-10 and its receptor, as well as
its in vivo function in health and disease.
