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      Abbreviated MRI of the Breast: Does It Provide Value?

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          Abstract

          MRI of the breast is the most sensitive test for breast cancer detection and outperforms conventional imaging with mammography, digital breast tomosynthesis, or ultrasound. However, the long scan time and relatively high costs limit its widespread use. Hence, it is currently only routinely implemented in the screening of women at an increased risk of breast cancer. To overcome these limitations, abbreviated dynamic contrast‐enhanced (DCE)‐MRI protocols have been introduced that substantially shorten image acquisition and interpretation time while maintaining a high diagnostic accuracy. Efforts to develop abbreviated MRI protocols reflect the increasing scrutiny of the disproportionate contribution of radiology to the rising overall healthcare expenditures. Healthcare policy makers are now focusing on curbing the use of advanced imaging examinations such as MRI while continuing to promote the quality and appropriateness of imaging. An important cornerstone of value‐based healthcare defines value as the patient's outcome over costs. Therefore, the concept of a fast, abbreviated MRI exam is very appealing, given its high diagnostic accuracy coupled with the possibility of a marked reduction in the cost of an MRI examination. Given recent concerns about gadolinium‐based contrast agents, unenhanced MRI techniques such as diffusion‐weighted imaging (DWI) are also being investigated for breast cancer diagnosis. Although further larger prospective studies, standardized imaging protocol, and reproducibility studies are necessary, initial results with abbreviated MRI protocols suggest that it seems feasible to offer screening breast DCE‐MRI to a broader population. This article aims to give an overview of abbreviated and fast breast MRI protocols, their utility for breast cancer detection, and their emerging role in the new value‐based healthcare paradigm that has replaced the fee‐for‐service model.

          Level of Evidence: 1

          Technical Efficacy: Stage 2

          J. Magn. Reson. Imaging 2019;49:e85–e100.

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          Most cited references88

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          Magnetic resonance imaging of the breast: recommendations from the EUSOMA working group.

          The use of breast magnetic resonance imaging (MRI) is rapidly increasing. EUSOMA organised a workshop in Milan on 20-21st October 2008 to evaluate the evidence currently available on clinical value and indications for breast MRI. Twenty-three experts from the disciplines involved in breast disease management - including epidemiologists, geneticists, oncologists, radiologists, radiation oncologists, and surgeons - discussed the evidence for the use of this technology in plenary and focused sessions. This paper presents the consensus reached by this working group. General recommendations, technical requirements, methodology, and interpretation were firstly considered. For the following ten indications, an overview of the evidence, a list of recommendations, and a number of research issues were defined: staging before treatment planning; screening of high-risk women; evaluation of response to neoadjuvant chemotherapy; patients with breast augmentation or reconstruction; occult primary breast cancer; breast cancer recurrence; nipple discharge; characterisation of equivocal findings at conventional imaging; inflammatory breast cancer; and male breast. The working group strongly suggests that all breast cancer specialists cooperate for an optimal clinical use of this emerging technology and for future research, focusing on patient outcome as primary end-point. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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            Swedish two-county trial: impact of mammographic screening on breast cancer mortality during 3 decades.

            To estimate the long-term (29-year) effect of mammographic screening on breast cancer mortality in terms of both relative and absolute effects. This study was carried out under the auspices of the Swedish National Board of Health and Welfare. The board determined that, because randomization was at a community level and was to invitation to screening, informed verbal consent could be given by the participants when they attended the screening examination. A total of 133 065 women aged 40-74 years residing in two Swedish counties were randomized into a group invited to mammographic screening and a control group receiving usual care. Case status and cause of death were determined by the local trial end point committees and, independently, by an external committee. Mortality analysis was performed by using negative binomial regression. There was a highly significant reduction in breast cancer mortality in women invited to screening according to both local end point committee data (relative risk [RR] = 0.69; 95% confidence interval: 0.56, 0.84; P < .0001) and consensus data (RR = 0.73; 95% confidence interval: 0.59, 0.89; P = .002). At 29 years of follow-up, the number of women needed to undergo screening for 7 years to prevent one breast cancer death was 414 according to local data and 519 according to consensus data. Most prevented breast cancer deaths would have occurred (in the absence of screening) after the first 10 years of follow-up. Invitation to mammographic screening results in a highly significant decrease in breast cancer-specific mortality. Evaluation of the full impact of screening, in particular estimates of absolute benefit and number needed to screen, requires follow-up times exceeding 20 years because the observed number of breast cancer deaths prevented increases with increasing time of follow-up.
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              Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR

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                Author and article information

                Contributors
                pinkerdk@mskcc.org
                Journal
                J Magn Reson Imaging
                J Magn Reson Imaging
                10.1002/(ISSN)1522-2586
                JMRI
                Journal of Magnetic Resonance Imaging
                John Wiley and Sons Inc. (Hoboken )
                1053-1807
                1522-2586
                08 September 2018
                June 2019
                : 49
                : 7 , Special Issue on the Value of MRI ( doiID: 10.1002/jmri.v49.7 )
                : e85-e100
                Affiliations
                [ 1 ] Department of Radiology Breast Imaging Service, Memorial Sloan Kettering Cancer Center New York New York USA
                [ 2 ] Department of Diagnostic and Interventional Radiology University Hospital Frankfurt Frankfurt Germany
                [ 3 ] Department of Radiology Center for Biomedical Imaging, NYU School of Medicine New York New York USA
                [ 4 ] Department of Biomedical Sciences and Morphologic and Functional Imaging University of Messina Messina Italy
                [ 5 ] Department of Biomedical Imaging and Image‐guided Therapy, Division of Molecular and Gender Imaging Medical University Vienna Vienna Austria
                Author notes
                [*] [* ]Address reprint requests to: K.P., Breast Imaging Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 300 E. 66 th St., 7 th Fl., New York, NY 10065. E‐mail: pinkerdk@ 123456mskcc.org
                Article
                JMRI26291
                10.1002/jmri.26291
                6408315
                30194749
                62769268-f8ab-4fff-8767-17149d80c288
                © 2018 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

                History
                : 23 May 2018
                : 26 July 2018
                : 26 July 2018
                Page count
                Figures: 10, Tables: 1, Pages: 18, Words: 9884
                Funding
                Funded by: NIH/NCI Cancer Center
                Award ID: P30 CA008748
                Funded by: Memorial Sloan Kettering Cancer Center
                Funded by: Breast Cancer Research Foundation
                Funded by: Memorial Sloan Kettering Cancer Center
                Funded by: NIH
                Award ID: P41 EB017183
                Categories
                Review Article
                Review Articles
                Custom metadata
                2.0
                jmri26291
                June 2019
                Converter:WILEY_ML3GV2_TO_NLMPMC version:5.6.4 mode:remove_FC converted:24.06.2019

                Radiology & Imaging
                breast mri,abbreviated mri,breast cancer,gadolinium‐based contrast agents,unenhanced,diffusion‐weighted imaging

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