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      Posterior capsule opacification

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          Abstract

          A complication of extracapsular cataract extraction with or without posterior chamber intraocular lens (PC-IOL) implantation is posterior capsule opacification. This condition is usually secondary to a proliferation and migration of residual lens epithelial cells. Opacification may be reduced by atraumatic surgery and thorough cortical clean-up. Clinical, pathological and experimental studies have shown that use of hydrodissection, the continuous curvilinear capsulorhexis and specific IOL designs may help reduce the incidence of this complication. Capsular-fixated, one-piece all-polymethylmethacrylate PC-IOLs with a C-shaped loop configuration and a posterior convexity of the optic are effective. Polymethylmethacrylate loops that retain "memory" create a symmetric, radial stretch on the posterior capsule after in-the-bag placement, leading to a more complete contact between the posterior surface of the IOL optic and the taut capsule. This may help form a barrier against central migration of epithelial cells into the visual axis. Various pharmacological and immunological methods are being investigated but conclusive data on these modalities are not yet available.

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          Author and article information

          Journal
          Survey of Ophthalmology
          Survey of Ophthalmology
          Elsevier BV
          00396257
          September 1992
          September 1992
          : 37
          : 2
          : 73-116
          Article
          10.1016/0039-6257(92)90073-3
          1455302
          62435ffc-599e-4a3b-afa4-041a126a9651
          © 1992

          http://www.elsevier.com/tdm/userlicense/1.0/

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