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      Synaptic theory of working memory.

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          Abstract

          It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the refresh rate can be low, resulting in a mechanism that is metabolically efficient and robust. The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Mar 14 2008
          : 319
          : 5869
          Affiliations
          [1 ] Group for Neural Theory, Département d'Etudes Cognitives, Ecole Normale Supérieure et Collège-de-France, Paris, France.
          Article
          319/5869/1543
          10.1126/science.1150769
          18339943
          6216b49c-587d-49f0-8fdd-46958495345c
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