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      Outcome of Induction and Associated Factors among Term and Post-Term Mothers Managed at Jimma University Specialized Hospital: A Two Years' Retrospective Analysis

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          Abstract

          Background

          Induction of labor using oxytocin is a routine procedure in obstetrics used for vaginal delivery of gravid uterus. The purpose of this study was to analyze outcome of induction with oxytocin and associated factors among mothers who delivered at term and post-term in Jimma University Specialized Hospital, Southwest Ethiopia.

          Methods

          A facility based cross-sectional study was conducted on records of 280 laboring mothers who delivered at term and post-term after induction with oxytocin from September 1 st, 2009 to August 31 st, 2011. The data were extracted using checklist and analyzed using SPSS windows version 16.0. The level of significance to declare relationship between the dependent and independent variables was set at p< 0.05.

          Results

          Mean maximum oxytocin levels used until vaginal delivery and at time of diagnosis of failed induction were 55.0 ± 29.8 and 89.7± 11.6 miu/min respectively. Mean time elapsed from initiation of induction with oxytocin to vaginal delivery and till diagnosis of failed induction were 6:10 ± 3:09 and 9:57± 2:01 hours respectively. Failed induction was diagnosed in 21.4% of the mothers. Primigravidity, unfavorable and intermediate Bishop Scores determined at admission were found to be predictors of failed induction.

          Conclusion

          High rate of failed induction and high level of oxytocin use were found. Preparation of the cervix before commencing induction in primigravid women is recommended to improve success of induction with the current protocol.

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          Most cited references22

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          Bishop score and risk of cesarean delivery after induction of labor in nulliparous women.

          To quantify the risk and risk factors for cesarean delivery associated with medical and elective induction of labor in nulliparous women. A prospective cohort study was performed in nulliparous women at term with vertex singleton gestations who had labor induced at 2 obstetrical centers. Medical and elective indications and Bishop scores were recorded before labor induction. Obstetric and neonatal data were analyzed and compared with the results in women with a spontaneous onset of labor. Data were analyzed using univariate and multivariable regression modeling. A total of 1,389 women were included in the study. The cesarean delivery rate was 12.0% in women with a spontaneous onset of labor (n = 765), 23.4% in women undergoing labor induction for medical reasons (n = 435) (unadjusted odds ratio [OR] 2.24; 95% confidence interval [CI] 1.64-3.06), and 23.8% in women whose labor was electively induced (n = 189) (unadjusted OR 2.29; 95% CI 1.53-3.41). However, after adjusting for the Bishop score at admission, no significant differences in cesarean delivery rates were found among the 3 groups. A Bishop score of 5 or less was a predominant risk factor for a cesarean delivery in all 3 groups (adjusted OR 2.32; 95% CI 1.66-3.25). Other variables with significantly increased risk for cesarean delivery included maternal age of 30 years or older, body mass index of 31 or higher, use of epidural analgesia during the first stage of labor, and birth weight of 3,500 g or higher. In both induction groups, more newborns required neonatal care, more mothers needed a blood transfusion, and the maternal hospital stay was longer. Compared with spontaneous onset of labor, medical and elective induction of labor in nulliparous women at term with a single fetus in cephalic presentation is associated with an increased risk of cesarean delivery, predominantly related to an unfavorable Bishop score at admission. II-2.
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            Labor induction and the risk of a cesarean delivery among nulliparous women at term.

            To estimate the association of labor induction with the risk of a cesarean delivery for nulliparous women presenting at term at a regional hospital. This was a retrospective cohort study of cesarean delivery among nulliparous women delivering a live, singleton, vertex pregnancy at term. We used clinical data from electronic hospital obstetric records at a large, regional, obstetric hospital, approximating a population-based cohort. Multivariable logistic regression was used to explore risk factors associated with cesarean delivery, and the fraction of cesarean deliveries attributable to the use of labor induction was estimated. From a cohort of 24,679 women, 7,804 met inclusion criteria. Labor induction was used in 43.6% of cases, 39.9% of which were elective. Use of labor induction was associated with an increased odds of cesarean delivery (crude odds ratio 2.67, 2.40-2.96) and the association remained significant (adjusted odds ratio 1.93, 1.71-2.2) after adjustment for maternal demographic characteristics, medical risk, and pregnancy complications. The contribution of labor induction to cesarean delivery in this cohort was estimated to be approximately 20%. Labor induction is significantly associated with a cesarean delivery among nulliparous women at term for those with and without medical or obstetric complications. Reducing the use of elective labor induction may lead to decreased rates of cesarean delivery for a population. II.
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              Factors predicting labor induction success: a critical analysis.

              JOAN CRANE (2006)
              Because of the risk of failed induction of labor, a variety of maternal and fetal factors as well as screening tests have been suggested to predict labor induction success. Certain characteristics of the woman (including parity, age, weight, height and body mass index), and of the fetus (including birth weight and gestational age) are associated with the success of labor induction; with parous, young women who are taller and lower weight having a higher rate of induction success. Fetuses with a lower birth weight or increased gestational age are also associated with increased induction success. The condition of the cervix at the start of induction is an important predictor, with the modified Bishop score being a widely used scoring system. The most important element of the Bishop score is dilatation. Other predictors, including transvaginal ultrasound (TVUS) and biochemical markers [including fetal fibronectin (fFN)] have been suggested. Meta-analyses of studies identified from MEDLINE, PubMed, and EMBASE and published from 1990 to October 2005 were performed evaluating the use of TVUS and fFN in predicting labor induction success in women at term with singleton gestations. Both TVUS and Bishop score predicted successful induction [likelihood ratio (LR)=1.82, 95% confidence interval (CI)=1.51-2.20 and LR=2.10, 95%CI=1.67-2.64, respectively]. As well, fFN and Bishop score predicted successful induction (LR=1.49, 95%CI=1.20-1.85, and LR=2.62, 95%CI=1.88-3.64, respectively). Although TVUS and fFN predicted successful labor induction, neither has been shown to be superior to Bishop score. Further research is needed to evaluate these potential predictors and insulin-like growth factor binding protein-1 (IGFBP-1), another potential biochemical marker.
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                Author and article information

                Journal
                Ethiop J Health Sci
                Ethiop J Health Sci
                Ethiopian Journal of Health Sciences
                Research and Publications Office of Jimma University (Jimma, Ethiopia )
                1029-1857
                March 2016
                : 26
                : 2
                : 121-130
                Affiliations
                [1 ]Department of Gynecology and Obstetrics, Jimma University, Ethiopia
                Author notes
                Corresponding Author: Woubshet Girma, gwubdz@ 123456yahoo.com
                Article
                jEJHS.v26.i2.pg121
                10.4314/ejhs.v26i2.6
                4864341
                27222625
                61c7c285-7dfd-4d10-be31-bf786770bd41
                Copyright © Jimma University, Research & Publications Office 2016
                History
                Categories
                Original Article

                Medicine
                oxytocin,induction of labor,failed induction,successful induction,bishop score
                Medicine
                oxytocin, induction of labor, failed induction, successful induction, bishop score

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