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      Role of hedgehog signaling related non-coding RNAs in developmental and pathological conditions.

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          Abstract

          The hedgehog (Hh) signaling pathway is an evolutionarily conserved pathway that regulates embryonic development in vertebrates. However, strong evidence suggests the role of its dysregulation in human diseases, especially cancers. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), belong to a group of human transcriptomes that do not translate into proteins. However, they can highly influence protein expression. This review will provide a comprehensive link between ncRNAs and Hh signaling pathways in different human diseases and development, providing insights into disease and cancer progression as well as emphasizing their therapeutic, prognostic, and diagnostic significance.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Biomed Pharmacother
          Title: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
          Publisher: Elsevier BV
          ISSN (Electronic): 1950-6007
          ISSN (Print): 0753-3322
          Publication date (Electronic): Sep 2022
          Volume: 153
          Affiliations
          [1 ] Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: zanyar.hajiesmailpoor@gmail.com.
          [2 ] Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
          [3 ] Department of Microbiology, Faculty of Basic Sciences, Islamic Azad University, Zanjan, Iran.
          [4 ] Department of Biochemistry, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
          [5 ] Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
          [6 ] Graduated, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
          Article
          Publisher Item ID: S0753-3322(22)00896-4
          DOI: 10.1016/j.biopha.2022.113507
          PubMed ID: 36076513
          SO-VID: 61b29cad-64da-4014-907f-33eb4ddb6648
          History

          Keywords: Hedgehog pathway,circRNA,Development,Cancer,ncRNA,miRNA,lncRNA,Signaling pathway
          Data availability:
          Keywords: Hedgehog pathway, circRNA, Development, Cancer, ncRNA, miRNA, lncRNA, Signaling pathway

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