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      SGLT2 inhibitors: an evidence-based update on cardiovascular implications

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          2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

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            Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes.

            The effects of empagliflozin, an inhibitor of sodium-glucose cotransporter 2, in addition to standard care, on cardiovascular morbidity and mortality in patients with type 2 diabetes at high cardiovascular risk are not known.
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              Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction

              In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the presence or absence of type 2 diabetes.
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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Expert Opinion on Investigational Drugs
                Expert Opinion on Investigational Drugs
                Informa UK Limited
                1354-3784
                1744-7658
                September 02 2023
                October 02 2023
                September 02 2023
                : 32
                : 9
                : 839-847
                Affiliations
                [1 ]International Translational Research and Medical Education (ITME) Consortium, Academic Research Unit, Department of Advanced Biomedical Sciences, “Federico II” University, Naples, Italy
                [2 ]Department of Medicine (Division of Cardiology), Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York City, NY, USA
                [3 ]Department of Medicine, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Aging Research, Fleischer Institute for Diabetes and Metabolism (FIDAM), Albert Einstein College of Medicine, New York City, NY, USA
                [4 ]Department of Medicine and Health Sciences “Vincenzo Tiberio, University of Molise, Campobasso, Italy
                [5 ]Department of Molecular Pharmacology, Einstein-Mount Sinai Diabetes Research Center (ES-DRC), Einstein Institute for Neuroimmunology and Inflammation (INI), Albert Einstein College of Medicine, New York City, NY, USA
                Article
                10.1080/13543784.2023.2263354
                37740906
                608b8553-4b2e-405d-8879-8bb5c08cf4e8
                © 2023
                History

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