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Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry
Torbjörn Tomson ,
Dina Battino ,
Erminio Bonizzoni ,
John Craig ,
Dick Lindhout ,
Emilio Perucca ,
Anne Sabers ,
Sanjeev V Thomas ,
Frank Vajda ,
Francesca Faravelli ,
Chiara Pantaleoni ,
Elisabeth Robert-Gnansia ,
Leonor Cabral-Lim ,
Boštjan Čebular ,
Alejandro De Marinis ,
Reetta Kälviäinen ,
Ketevan Khomeriki ,
Gordana Kiteva-Trencevska ,
Silvia Kochen ,
Martin Kurthen ,
Gerhard Luef ,
Meritxell Martinez Ferri ,
Maja Milovanović ,
Karl Otto Nakken ,
Miri Neufeld ,
Hideyuki Ohtani ,
Aline Russell ,
Vladimír Safcák ,
Bettina Schmitz ,
Luigi Maria Specchio ,
Barbara Tettenborn ,
Eugene van Puijenbroek ,
Hsiang-Yu Yu ,
Jana Zarubova ,
Claus Albretsen ,
Silje Alvestad ,
Noemi Becser Andersen ,
Luisa Antonini ,
Jens Arentsen ,
Dag Aurlien ,
Ismael Barzinji ,
Juan Luis Becerra Cuñat ,
Natalia Bohorquez Morera ,
Martin J. Brodie ,
Eylert Brodtkorb ,
Laura Broglio ,
Elsebeth Bruun Christensen ,
Petr Bušek ,
Claudia Cagnetti ,
Maria Paola Canevini ,
Astrid Carius ,
Maria Dolores Castro Vilanova ,
Michela Cecconi ,
T-Y Chang ,
Jakob Christensen ,
Giovanni De Maria ,
Dieter Dennig ,
Brenda Diputado ,
Janne Marit Ertresvåg ,
Toni Escartin ,
Dominique Flügel ,
Birgitte Forsom Sondal ,
Nicoletta Foschi ,
Albertina Franza ,
Katsuyuki Fukushima ,
Antonio Gambardella ,
Iñigo Garamendi Ruiz ,
Helena Gauffin ,
Pia Gellert ,
Leif Gjerstad ,
Lisa Gordon ,
Katrine Haggag ,
Imad Halawa ,
Terttu Heikinheimo-Connell ,
Tim Hendgen ,
Zarouhi Hertz ,
Odo Hildenhagen ,
Stephanie Hödl ,
Ineke Hogenesch ,
Anette Huuse Farmen ,
Yushi Inoue ,
Stefan Juhl ,
Masaaki Kato ,
Germaine Kenou Van Rijckevorssel ,
E. Kluck ,
Hana Krijtová ,
Eva Kumlien ,
Angelo Labate ,
Theresa Lasch ,
Hans Lindsten ,
Renata Listonova ,
Rasmus Lossius ,
Anders Lundgren ,
Kristina Malmgren ,
Iva Marečková ,
Daniela Marino ,
Peter Mattsson ,
Aileen McGonigal ,
Katarzyna Miesczanleh ,
Masahiro Mizobuchi ,
Barbara Mostacci ,
Birgit Müffelmann ,
Uden Navn ,
Anders Nilsson ,
Bernhard Oehl ,
Andrea Ortenzi ,
Judith Osseforth ,
Aldo Paggi ,
Eliana Pastor ,
Birthe Pedersen ,
Vaiva Petrenaite ,
Pietro Pignatta ,
Isabel Pires ,
Alessandra Pistelli ,
Jesús Antonio Riuz Gimenez ,
Raffaele Rocchi ,
Lone Rodam ,
Reina Roivainen ,
Gisela Rytířová ,
Christian Samsonsen ,
Gemma Sansa Fayos ,
Anna Maija Saukkonen ,
Alma Sikiric ,
David Sopelana Garay ,
Bernhard Steinhoff ,
Maria Strandberg ,
Torleiv Svendsen ,
Erik Tauboll ,
Kiyohito Terada ,
Marina Trivisano ,
Katherine Turner ,
Mogens Worm ,
Elias Zakharia ,
Elena Zambrelli ,
Morteza Zarifi-Oskoie
June 2018
June 2018
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Abstract
Evidence for the comparative teratogenic risk of antiepileptic drugs is insufficient,
particularly in relation to the dosage used. Therefore, we aimed to compare the occurrence
of major congenital malformations following prenatal exposure to the eight most commonly
used antiepileptic drugs in monotherapy.