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      Metástasis Pancreática Metacrónica de un Carcinoma de Células Renales. Reporte de un Caso Translated title: Metachronic Pancreatic Metastasis of a Renal Cell Carcinoma. Case Report

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          Abstract

          RESUMEN: El carcinoma de células renales (CCR) a nivel mundial presenta una incidencia de 431.288 casos anuales, causando 179.368 muertes en 2020. Sin embargo, a pesar de su incidencia, el desarrollo de metástasis pancreática (MP) de un RCC es un hecho inusual. El objetivo de este manuscrito fue reportar el caso de una paciente con una MP metacrónica de un CCR. Se trata de una paciente de 56 años, sexo femenino, nefrectomizada derecha hace 132 meses por un CCR, en adyuvancia con inmunoterapia. En un control imagenológico de rutina, se le pesquisó una lesión de aspecto tumoral en el cuerpo y cola del páncreas. Se intervino quirúrgicamente, realizándose una pancreatectomía córporo-caudal con preservación esplénica. Evolucionó de forma satisfactoria, sin complicaciones, siendo dada de alta al 4º día de su cirugía. El informe del estudio de la pieza operatoria con estudio inmunohistoquímico concluyó que se trataba de una MP de CCR. La paciente se encuentra en buenas condiciones generales y reinició quimioterapia con anticuerpos monoclonales. El seguimiento frecuente y prolongado de pacientes con antecedentes de CCR, facilita un diagnóstico y tratamiento oportuno de MP facilitando el mejor pronóstico de los pacientes, con tasas más altas de supervivencia.

          Translated abstract

          SUMMARY: Renal cell carcinoma (RCC) worldwide has an incidence of 431,288 cases per year, causing 179,368 deaths in 2020. However, despite its incidence, the development of pancreatic metastasis (MP) from RCC is unusual. The aim of this manuscript was to report the case of a patient with a PM of a RCC. This is a 56-year-old female patient, underwent right nephrectomy 132 months earlier for RCC. While she was in adjuvant immunotherapy, in a routine imaging control, it was found a tumor lesion in the body and the tail of the pancreas. So, she underwent surgery, performing a corpora-caudal pancreatectomy with splenic preservation. Postoperative evolution was correct, without complications, and she was discharged on the 4th day after surgery. The report of the study of the surgical piece with an immunohistochemical study included, conclusive of PM of RCC. Currently, the patient is in good general condition and restarted chemotherapy with monoclonal antibodies. Frequent and prolonged follow-up of patients with a history of RCC facilitates timely diag- nosis and treatment of PM, facilitating the best prognosis for patients, with higher survival rates.

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          Most cited references52

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          The CARE Guidelines: Consensus-based Clinical Case Reporting Guideline Development

          Background: A case report is a narrative that describes, for medical, scientific, or educational purposes, a medical problem experienced by one or more patients. Case reports written without guidance from reporting standards are insufficiently rigorous to guide clinical practice or to inform clinical study design. Primary Objective: Develop, disseminate, and implement systematic reporting guidelines for case reports. Methods: We used a three-phase consensus process consisting of (1) premeeting literature review and interviews to generate items for the reporting guidelines, (2) a face-to-face consensus meeting to draft the reporting guidelines, and (3) postmeeting feedback, review, and pilot testing, followed by finalization of the case report guidelines. Results: This consensus process involved 27 participants and resulted in a 13-item checklist—a reporting guideline for case reports. The primary items of the checklist are title, key words, abstract, introduction, patient information, clinical findings, timeline, diagnostic assessment, therapeutic interventions, follow-up and outcomes, discussion, patient perspective, and informed consent. Conclusions: We believe the implementation of the CARE (CAse REport) guidelines by medical journals will improve the completeness and transparency of published case reports and that the systematic aggregation of information from case reports will inform clinical study design, provide early signals of effectiveness and harms, and improve healthcare delivery.
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            Systemic Therapy for Metastatic Renal-Cell Carcinoma

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              Evaluation of Clear Cell, Papillary, and Chromophobe Renal Cell Carcinoma Metastasis Sites and Association With Survival

              Key Points Question In metastatic renal cell carcinoma (RCC), do patterns of metastasis differ between histologic subtypes and are sites of metastasis associated with survival? Findings In this cohort studyincluding 10 105 patients, patterns of metastasis varied significantly between metastatic clear cell RCC, papillary RCC, and chromophobe RCC. Sites of metastasis were associated with survival in all histologic subtypes. Meaning These data highlight the clinical and biological variability between metastatic RCC histologic subtypes and suggest that patterns of metastasis may reflect differences in underlying disease biology.
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                Author and article information

                Journal
                ijmorphol
                International Journal of Morphology
                Int. J. Morphol.
                Sociedad Chilena de Anatomía (Temuco, , Chile )
                0717-9502
                October 2023
                : 41
                : 5
                : 1550-1557
                Affiliations
                [4] Azuay orgnameUniversidad del Azuay Ecuador
                [1] Temuco Araucanía orgnameUniversidad de La Frontera orgdiv1Doctorado en Ciencias Médicas Chile
                [5] Temuco Araucanía orgnameUniversidad de La Frontera Chile
                [2] orgnameNúcleo Milenio de Sociomedicina Chile
                [3] Temuco Araucanía orgnameUniversidad de La Frontera orgdiv1Centro de Estudios Morfológicos y Quirúrgicos Chile
                Article
                S0717-95022023000501550 S0717-9502(23)04100501550
                6071451a-31ab-4845-b3e8-20fc95d5dae5

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 12 July 2023
                : 17 August 2023
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 52, Pages: 8
                Product

                SciELO Chile

                Categories
                ARTÍCULOS

                "Neoplasias Pancreáticas","Carcinoma, Renal Cell/secondary"[Mesh],"Carcinoma, Renal Cell"[Mesh],"Pancreatic Neoplasms/surgery"[Mesh],"Pancreatic Neoplasms/secondary"[Mesh],"Pancreatic Neoplasms"[Mesh],"Carcinoma de Células Renales/secundario","Carcinoma, Células Renales","Neoplasias Pancreáticas/cirugía","Neoplasias Pancreáticas/secundarias"

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