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      The Economic Impact of Eradicating Peste des Petits Ruminants: A Benefit-Cost Analysis

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          Abstract

          Peste des petits ruminants (PPR) is an important cause of mortality and production loss among sheep and goats in the developing world. Despite control efforts in a number of countries, it has continued to spread across Africa and Asia, placing an increasing burden on the livelihoods of livestock keepers and on veterinary resources in affected countries. Given the similarities between PPR and rinderpest, and the lessons learned from the successful global eradication of rinderpest, the eradication of PPR seems appealing, both eliminating an important disease and improving the livelihoods of the poor in developing countries. We conducted a benefit-cost analysis to examine the economic returns from a proposed programme for the global eradication of PPR. Based on our knowledge and experience, we developed the eradication strategy and estimated its costs. The benefits of the programme were determined from (i) the averted mortality costs, based on an analysis of the literature, (ii) the downstream impact of reduced mortality using a social accounting matrix, and (iii) the avoided control costs based on current levels of vaccination. The results of the benefit-cost analysis suggest strong economic returns from PPR eradication. Based on a 15-year programme with total discounted costs of US$2.26 billion, we estimate discounted benefits of US$76.5 billion, yielding a net benefit of US$74.2 billion. This suggests a benefit cost ratio of 33.8, and an internal rate of return (IRR) of 199%. As PPR mortality rates are highly variable in different populations, we conducted a sensitivity analysis based on lower and higher mortality scenarios. All the scenarios examined indicate that investment in PPR eradication would be highly beneficial economically. Furthermore, removing one of the major constraints to small ruminant production would be of considerable benefit to many of the most vulnerable communities in Africa and Asia.

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          Most cited references17

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          Global distribution of peste des petits ruminants virus and prospects for improved diagnosis and control.

          Viral diseases of farm animals, rather than being a diminishing problem across the world, are now appearing with regularity in areas where they have never been seen before. Across the developing world, viral pathogens such as peste des petits ruminants virus (PPRV) place a huge disease burden on agriculture, in particular affecting small ruminant production and in turn increasing poverty in some of the poorest parts of the world. PPRV is currently considered as one of the main animal transboundary diseases that constitutes a threat to livestock production in many developing countries, particularly in western Africa and south Asia. Infection of small ruminants with PPRV causes a devastating plague and as well as being endemic across much of the developing world, in recent years outbreaks of PPRV have occurred in the European part of Turkey. Indeed, the relevance of many once considered 'exotic' viruses is now also high across the European Union and may threaten further regions across the globe in the future. Here, we review the spread of PPRV across Africa, Asia and into Europe through submissions made to the OIE Regional Reference Laboratories. Further, we discuss current control methods and the development of further tools to aid both diagnosis of the disease and prevention.
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            An outbreak of peste des petits ruminants (PPR) in camels in the Sudan.

            In mid-August 2004, an outbreak of a previously unknown fatal disease of camels was reported to Kassala State veterinary authorities. Several areas in the state were visited during August-October 2004 to collect epidemiological data and specimens for diagnosis. Clinically the disease was characterized by sudden death of apparently healthy animals and yellowish and later bloody diarrhea and abortion. The disease outbreaks coincided with the seasonal movement of animals towards autumn green pasture. Death was always sudden and proceeded with colic and difficulty in respiration. Mortality rate ranged between 0% and 50% and vary in accordance with the area with a mean of 7.4%. More than 80% of deaths were in pregnant and recently-delivered she-camels. All age, sex and breed groups were affected but more than 50% of deaths were reported in adult animals in comparison to calves and young camels. The main post-mortem findings include lung congestion and consolidation, paleness and fragility of liver, enlarged lymph nodes and congestion and hemorrhage of small intestine and stomach. Agar gel diffusion test (AGDT), RT-PCR and virus isolation in cell culture gave positive results for peste des petits ruminants virus (PPRV), a virus belonging to the Morbillivirus, Genus, member of the family Paramyxoviridae. The effect of this new devastating disease on camel production in the affected area was discussed as well as proposals for future research. Copyright © 2010 Elsevier B.V. All rights reserved.
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              A real time RT-PCR assay for the specific detection of Peste des petits ruminants virus.

              Peste des petits ruminants virus (PPRV) causes a devastating disease of small ruminants present across much of Africa and Asia. Recent surveillance activities and phylogenetic analyses have suggested that the virus is an emerging problem as it is now being detected in areas previously free of the disease. As such, the virus not only is threatening small ruminant production and agricultural stability in the developing world, but also poses an economic threat to livestock in the European Union (EU) through introduction from European Turkey and North Africa. This report describes the development of a high throughput, rapid, real time RT-PCR method for the sensitive and specific detection of PPRV using robotic RNA extraction. This assay targets the nucleocapsid (N) gene of PPRV and has been shown to detect all four genetic lineages of PPRV in tissues, ocular and nasal swabs and blood samples collected in the field. The lowest detection limit achieved was approximately 10 genome copies/reaction, making this assay an ideal tool for the sensitive and rapid detection of PPRV in diagnostic laboratories. © 2010 Elsevier B.V. All rights reserved.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                22 February 2016
                2016
                : 11
                : 2
                : e0149982
                Affiliations
                [1 ]Production and Population Health Department, Royal Veterinary College, University of London, Hatfield, United Kingdom
                [2 ]Lab 863 Limited, Edgware, United Kingdom, and Norwegian Institute of International Affairs, Oslo, Norway
                [3 ]Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
                [4 ]The Nelson Mandela African Institute of Science and Technology, Arusha, Tanzania
                [5 ]Geelong Centre for Emerging Infectious Disease, Medical Faculty, Deakin University, Geelong, Australia
                [6 ]Bill and Melinda Gates Foundation, Seattle, Washington, United States of America
                [7 ]Scotland’s Rural College, Edinburgh, United Kingdom
                [8 ]Taurus Animal Health, Headley Down, Hampshire, United Kingdom
                Indian Institute of Science, INDIA
                Author notes

                Competing Interests: During the preparation of this paper, KR was employed by commercial company, Lab 863 Limited, and ARP is employed by the independent consultancy company, Arpexas Limited. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

                Conceived and designed the experiments: BAJ KMR JCM JA MJ ST YC ARP PR. Performed the experiments: BAJ KMR JCM JA MJ ST YC ARP PR. Analyzed the data: BAJ KMR JCM JA MJ ST YC ARP PR. Contributed reagents/materials/analysis tools: BAJ KMR JCM. Wrote the paper: BAJ KMR JCM JA MJ ST YC ARP PR.

                [¤]

                Current address: Faculty of Agribusiness and Commerce, Lincoln University, Christchurch, New Zealand

                Article
                PONE-D-15-25934
                10.1371/journal.pone.0149982
                4764769
                26900944
                6048f5fa-4c43-4a14-9373-c1e4e32d6237
                © 2016 Jones et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 14 June 2015
                : 2 February 2016
                Page count
                Figures: 3, Tables: 2, Pages: 18
                Funding
                This paper is based on research funded by the Bill & Melinda Gates Foundation ( http://www.gatesfoundation.org/). The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation. ST and YC are employees of The Bill and Melinda Gates Foundation. BAJ, KMR, JCM, JA, MJ, ARP and PR were funded by the Gates Foundation to carry out the study. There was no additional external funding received for this study. The funder provided support in the form of salaries (ST, YC) or honoraria (BAJ, KMR, JCM, JA, MJ, ARP and PR) but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.
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