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      Lipids in regulating oligodendrocyte structure and function

      Seminars in Cell & Developmental Biology
      Elsevier BV

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          mTOR Signaling in Growth, Metabolism, and Disease.

          The mechanistic target of rapamycin (mTOR) coordinates eukaryotic cell growth and metabolism with environmental inputs, including nutrients and growth factors. Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process. Here, we review recent advances in our understanding of mTOR function, regulation, and importance in mammalian physiology. We also highlight how the mTOR signaling network contributes to human disease and discuss the current and future prospects for therapeutically targeting mTOR in the clinic.
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            Understanding the diversity of membrane lipid composition

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              Cellular fatty acid metabolism and cancer.

              Cancer cells often have characteristic changes in metabolism. Cellular proliferation, a common feature of all cancers, requires fatty acids for synthesis of membranes and signaling molecules. Here, we provide a view of cancer cell metabolism from a lipid perspective, and we summarize evidence that limiting fatty acid availability can control cancer cell proliferation. Copyright © 2013 Elsevier Inc. All rights reserved.
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                Author and article information

                Journal
                Seminars in Cell & Developmental Biology
                Seminars in Cell & Developmental Biology
                Elsevier BV
                10849521
                April 2021
                April 2021
                : 112
                : 114-122
                Article
                10.1016/j.semcdb.2020.07.016
                32912639
                60373c05-d75a-4246-9374-266afc5bc50a
                © 2021

                https://www.elsevier.com/tdm/userlicense/1.0/

                http://creativecommons.org/licenses/by-nc-nd/4.0/

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