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      Artificial Intelligence in Intensive Care Medicine: Bibliometric Analysis

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          Abstract

          Background

          Interest in critical care–related artificial intelligence (AI) research is growing rapidly. However, the literature is still lacking in comprehensive bibliometric studies that measure and analyze scientific publications globally.

          Objective

          The objective of this study was to assess the global research trends in AI in intensive care medicine based on publication outputs, citations, coauthorships between nations, and co-occurrences of author keywords.

          Methods

          A total of 3619 documents published until March 2022 were retrieved from the Scopus database. After selecting the document type as articles, the titles and abstracts were checked for eligibility. In the final bibliometric study using VOSviewer, 1198 papers were included. The growth rate of publications, preferred journals, leading research countries, international collaborations, and top institutions were computed.

          Results

          The number of publications increased steeply between 2018 and 2022, accounting for 72.53% (869/1198) of all the included papers. The United States and China contributed to approximately 55.17% (661/1198) of the total publications. Of the 15 most productive institutions, 9 were among the top 100 universities worldwide. Detecting clinical deterioration, monitoring, predicting disease progression, mortality, prognosis, and classifying disease phenotypes or subtypes were some of the research hot spots for AI in patients who are critically ill. Neural networks, decision support systems, machine learning, and deep learning were all commonly used AI technologies.

          Conclusions

          This study highlights popular areas in AI research aimed at improving health care in intensive care units, offers a comprehensive look at the research trend in AI application in the intensive care unit, and provides an insight into potential collaboration and prospects for future research. The 30 articles that received the most citations were listed in detail. For AI-based clinical research to be sufficiently convincing for routine critical care practice, collaborative research efforts are needed to increase the maturity and robustness of AI-driven models.

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          Most cited references27

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          MIMIC-III, a freely accessible critical care database

          MIMIC-III (‘Medical Information Mart for Intensive Care’) is a large, single-center database comprising information relating to patients admitted to critical care units at a large tertiary care hospital. Data includes vital signs, medications, laboratory measurements, observations and notes charted by care providers, fluid balance, procedure codes, diagnostic codes, imaging reports, hospital length of stay, survival data, and more. The database supports applications including academic and industrial research, quality improvement initiatives, and higher education coursework.
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            The eICU Collaborative Research Database, a freely available multi-center database for critical care research

            Critical care patients are monitored closely through the course of their illness. As a result of this monitoring, large amounts of data are routinely collected for these patients. Philips Healthcare has developed a telehealth system, the eICU Program, which leverages these data to support management of critically ill patients. Here we describe the eICU Collaborative Research Database, a multi-center intensive care unit (ICU)database with high granularity data for over 200,000 admissions to ICUs monitored by eICU Programs across the United States. The database is deidentified, and includes vital sign measurements, care plan documentation, severity of illness measures, diagnosis information, treatment information, and more. Data are publicly available after registration, including completion of a training course in research with human subjects and signing of a data use agreement mandating responsible handling of the data and adhering to the principle of collaborative research. The freely available nature of the data will support a number of applications including the development of machine learning algorithms, decision support tools, and clinical research.
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              Web of Science as a data source for research on scientific and scholarly activity

              Web of Science (WoS) is the world’s oldest, most widely used and authoritative database of research publications and citations. Based on the Science Citation Index, founded by Eugene Garfield in 1964, it has expanded its selective, balanced, and complete coverage of the world’s leading research to cover around 34,000 journals today. A wide range of use cases are supported by WoS from daily search and discovery by researchers worldwide through to the supply of analytical data sets and the provision of specialized access to raw data for bibliometric partners. A long- and well-established network of such partners enables the Institute for Scientific Information (ISI) to continue to work closely with bibliometric groups around the world to the benefit of both the community and the services that the company provides to researchers and analysts.
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                Author and article information

                Contributors
                Journal
                J Med Internet Res
                J Med Internet Res
                JMIR
                Journal of Medical Internet Research
                JMIR Publications (Toronto, Canada )
                1439-4456
                1438-8871
                November 2022
                30 November 2022
                : 24
                : 11
                : e42185
                Affiliations
                [1 ] Department of Intensive Care Medicine Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
                Author notes
                Corresponding Author: Shuyi Zhang shuishui286@ 123456qq.com
                Author information
                https://orcid.org/0000-0003-0137-2917
                https://orcid.org/0000-0002-4258-6391
                https://orcid.org/0000-0002-7520-6391
                https://orcid.org/0000-0002-0070-4556
                https://orcid.org/0000-0003-3777-140X
                Article
                v24i11e42185
                10.2196/42185
                9752463
                36449345
                5fec610a-8ed3-426d-91d1-2c6b35d45caf
                ©Ri Tang, Shuyi Zhang, Chenling Ding, Mingli Zhu, Yuan Gao. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 30.11.2022.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on https://www.jmir.org/, as well as this copyright and license information must be included.

                History
                : 27 August 2022
                : 8 October 2022
                : 23 October 2022
                : 31 October 2022
                Categories
                Original Paper
                Original Paper

                Medicine
                intensive care medicine,artificial intelligence,bibliometric analysis,machine learning,sepsis

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