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      Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial.

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          Abstract

          Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on therapy to standard of care for patients with severe eosinophilic asthma, has been shown in previous studies to reduce exacerbations and dependency on oral corticosteroids compared with placebo. We aimed to further assess mepolizumab in patients with severe eosinophilic asthma by examining its effect on health-related quality of life (HRQOL).

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          Author and article information

          Journal
          Lancet Respir Med
          The Lancet. Respiratory medicine
          Elsevier BV
          2213-2619
          2213-2600
          May 2017
          : 5
          : 5
          Affiliations
          [1 ] Yale Center for Asthma and Airway Disease, Yale School of Medicine, New Haven, CT, USA. Electronic address: geoffrey.chupp@yale.edu.
          [2 ] Respiratory Therapeutic Area, GlaxoSmithKline (GSK), Research Triangle Park, NC, USA.
          [3 ] Respiratory Medical Franchise, GSK, Research Triangle Park, NC, USA.
          [4 ] Clinical Statistics, GSK, Stockley Park, Middlesex, UK.
          [5 ] Respiratory Therapy Area, GSK, Stockley Park, Middlesex, UK.
          [6 ] Value Evidence and Outcomes, GSK, Collegeville, PA, USA.
          [7 ] Division of Pulmonary, Allergy & Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
          [8 ] l'Institut du Thorax, Universite de Nantes, CHU de Nantes, Nantes, France.
          [9 ] Department of Respiratory Medicine, Medical Centre Leeuwarden, Leeuwarden, Netherlands.
          Article
          S2213-2600(17)30125-X
          10.1016/S2213-2600(17)30125-X
          28395936
          5fc6ced8-ee26-45cf-897f-6f7ed56b0ad4
          History

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