Wanchao Yin:
ORCID: https://orcid.org/0000-0002-6889-4907
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review
& editing
Youwei Xu:
ORCID: https://orcid.org/0000-0001-8069-7511
Role: Formal analysisRole: InvestigationRole: ValidationRole: VisualizationRole: Writing
- original draft
Peiyu Xu:
ORCID: https://orcid.org/0000-0003-3590-4037
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
ValidationRole: VisualizationRole: Writing - original draftRole: Writing - review
& editing
Xiaodan Cao:
ORCID: https://orcid.org/0000-0002-6458-4805
Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole: VisualizationRole:
Writing - original draftRole: Writing - review & editing
Canrong Wu:
ORCID: https://orcid.org/0000-0002-2272-3838
Role: Formal analysisRole: Funding acquisitionRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: SupervisionRole: VisualizationRole: Writing
- review & editing
Chunyin Gu:
ORCID: https://orcid.org/0000-0001-8571-7411
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole: ValidationRole:
Writing - original draftRole: Writing - review & editing
Xinheng He:
ORCID: https://orcid.org/0000-0001-7813-5480
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: ResourcesRole: VisualizationRole: Writing - original draftRole: Writing
- review & editing
Xiaoxi Wang:
ORCID: https://orcid.org/0000-0002-4274-5698
Role: InvestigationRole: Validation
Sijie Huang:
ORCID: https://orcid.org/0000-0001-5653-0260
Role: Formal analysisRole: InvestigationRole: Validation
Qingning Yuan: Role: InvestigationRole: Visualization
Kai Wu: Role: Formal analysisRole: Investigation
Wen Hu: Role: Investigation
Zifu Huang:
ORCID: https://orcid.org/0000-0001-9436-4590
Role: Data curationRole: ResourcesRole: Software
Jia Liu: Role: Data curationRole: Formal analysisRole: ResourcesRole: Visualization
Zongda Wang:
ORCID: https://orcid.org/0000-0002-1662-2934
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: Writing
- original draftRole: Writing - review & editing
Fangfang Jia: Role: Formal analysisRole: Funding acquisitionRole: InvestigationRole: Writing - original
draft
Kaiwen Xia:
ORCID: https://orcid.org/0000-0002-1336-8790
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: ResourcesRole:
ValidationRole: Writing - original draftRole: Writing - review & editing
Peipei Liu: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: ValidationRole: VisualizationRole: Writing - original draftRole:
Writing - review & editing
Xueping Wang:
ORCID: https://orcid.org/0000-0002-2564-8714
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: Project administrationRole:
SupervisionRole: VisualizationRole: Writing - original draftRole: Writing - review
& editing
Bin Song:
ORCID: https://orcid.org/0000-0002-5327-5839
Role: Formal analysisRole: InvestigationRole: Validation
Jie Zheng:
ORCID: https://orcid.org/0000-0001-7932-5753
Role: Data curationRole: Formal analysisRole: InvestigationRole: ResourcesRole: ValidationRole:
Visualization
Hualiang Jiang:
ORCID: https://orcid.org/0000-0003-0656-6315
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: SupervisionRole: Validation
Xi Cheng:
ORCID: https://orcid.org/0000-0003-3081-3750
Role: Formal analysisRole: InvestigationRole: Project administrationRole: ResourcesRole:
Visualization
Yi Jiang:
ORCID: https://orcid.org/0000-0002-0723-1413
Role: Funding acquisitionRole: VisualizationRole: Writing - original draftRole: Writing
- review & editing
Su-Jun Deng:
ORCID: https://orcid.org/0000-0001-9266-0644
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole: ValidationRole:
VisualizationRole: Writing - original draftRole: Writing - review & editing
H. Eric Xu:
ORCID: https://orcid.org/0000-0002-6829-8144
Role: ConceptualizationRole: Data curationRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: SupervisionRole: ValidationRole: VisualizationRole: Writing
- original draftRole: Writing - review & editing
Journal ID (nlm-ta): Science
Journal ID (iso-abbrev): Science
Journal ID (publisher-id): science
Title:
Science (New York, N.y.)
Publisher:
American Association for the Advancement of Science
ISSN
(Print):
0036-8075
ISSN
(Electronic):
1095-9203
Publication date
(Electronic, pub):
08
February
2022
Publication date PMC-release: 08
February
2022
Electronic Location Identifier: eabn8863
Affiliations
[
1
]The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica,
Chinese Academy of Sciences, Shanghai 201203, China.
[
2
]Shanghai Jemincare Pharmaceuticals Co., Ltd., Shanghai 201203, China.
[
3
]University of Chinese Academy of Sciences, Beijing 100049, China.
[
4
]The Shanghai Advanced Electron Microscope Center, Shanghai Institute of Materia Medica,
Chinese Academy of Sciences, Shanghai 201203, China.
[
5
]State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese
Academy of Sciences, Shanghai 201203, China.
[
6
]Immunological Disease Research Center, Shanghai Institute of Materia Medica, Chinese
Academy of Sciences, .Shanghai 201203, China.
[
7
]School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China.
Author notes
[†]
These authors contributed equally to this work.
Author information
Article
Publisher ID:
abn8863
DOI: 10.1126/science.abn8863
PMC ID: 8939775
PubMed ID: 35133176
SO-VID: 5fbafcdc-c112-4ad1-9390-590ab469f9a3
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for the Advancement of Science. No claim to original U.S. Government Works. Distributed
under a Creative Commons Attribution License 4.0 (CC BY).
License:
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the original work is properly cited.