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      Limb reconstruction in a resource-limited environment

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          Abstract

          Introduction: Limb salvage and reconstruction are often challenging and even more so in the limited resource setting. The purpose of this narrative review is to explore the strategies for addressing the unique obstacles and opportunities of limb reconstructive surgery in resource-limited environments globally. Methods: We review (1) the global burden and dimension of the problem, (2) the relevance of orthopedic forums and communication, (3) free and open-access software for deformity analysis and correction, (4) bidirectional learning opportunities, and the value of fellowships and mentoring between resource-rich and resource-limited countries, and (5) how societies like SICOT can help to tackle the problem. Finally, case examples are presented to demonstrate the choice of surgical implants, their availability in regions with limited resources, and how the universal principles of limb reconstruction can be applied, irrespective of resource availability. Results: Limb reconstruction can often be life-changing surgery with the goals of limb salvage, improved function, and ambulation. The contradiction of relatively few severe limb deformities in high-income countries (HICs) with abundant resources and the considerable burden of limb deformities in resource-limited countries is striking. Free, open access to education and software planning tools are of paramount importance to achieve this goal of limb reconstruction. Bidirectional learning, i.e., knowledge exchange between individual surgeons and societies with limited and abundant resources, can be reached via fellowships and mentoring. The presented cases highlight (1) fixator-assisted wound closure obliviating the need for plastic surgery, (2) open bone transport, and (3) hinged Ilizarov frames for correction of severe deformities. These cases underline that optimal clinical outcome can be achieved with low-cost and readily available implants when the principles of limb reconstruction are skillfully applied. Discussion: Limb lengthening and reconstruction are based on universally applicable principles. These have to be applied regardless of the planning tool or surgical implant availability to achieve the goals of limb salvage and improved quality of life.

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          Most cited references58

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          The Impact of Trauma Care Systems in Low- and Middle-Income Countries.

          Injury is a leading cause of death globally, and organized trauma care systems have been shown to save lives. However, even though most injuries occur in low- and middle-income countries (LMICs), most trauma care research comes from high-income countries where systems have been implemented with few resource constraints. Little context-relevant guidance exists to help policy makers set priorities in LMICs, where resources are limited and where trauma care may be implemented in distinct ways. We have aimed to review the evidence on the impact of trauma care systems in LMICs through a systematic search of 11 databases. Reports were categorized by intervention and outcome type and summarized. Of 4,284 records retrieved, 71 reports from 32 countries met inclusion criteria. Training, prehospital systems, and overall system organization were the most commonly reported interventions. Quality-improvement, costing, rehabilitation, and legislation and governance were relatively neglected areas. Included reports may inform trauma care system planning in LMICs, and noted gaps may guide research and funding agendas.
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            The use of gentamicin-coated nails in the tibia: preliminary results of a prospective study

            Background The use of antibiotic-coated implants may reduce the rate of infection and facilitate fracture healing after surgical treatment of tibial shaft fractures. A new biodegradable gentamicin-loaded coating of an implant (UTN PROtect®) was CE-certified in August 2005. In this prospective, non-randomized case series, we investigated the clinical, laboratory and radiological outcomes of 21 patients who underwent surgical treatment in closed or open tibial fractures, as well as revisions with the UTN PROtect® gentamicin-coated intramedullary nail. Methods Of 21 patients (13 men, 8 women), 19 completed the 6-month follow-up. The study population included patients with complex tibial fractures and late revision cases. Clinical outcomes comprised adverse events, including infections and the SF-36 physical score. Laboratory outcomes, including C-reactive protein and leukocyte count as inflammatory markers, haemoglobin and serum gentamicin, were measured at baseline and up to 6 months post operatively. Radiographic assessments of fracture healing and weight-bearing capacity were determined at 5 weeks, 3 and 6 months after surgery. Results No implant-related infections occurred; one patient had superficial wound healing problems. Mean C-reactive protein levels remained below 5 mg/L throughout the study, with a peak at 4–7 days after surgery (4.4 mg/L; range 0.5–16.1 mg/L). Leukocyte counts and haemoglobin levels did not vary over time during the study. The mean SF-36 physical score at 6 months was 42.6 (range 19.4–56.7). Radiographic union defined as three or four bridged cortices was achieved in 11 patients (58%) after 6 months. The remaining eight patients showed partial fracture healing with one or two bridged cortices. Additionally, 13 patients (68%) demonstrated full weight-bearing capacity after 6 months. Conclusions The use of the UTN PROtect® intramedullary nail was associated with good clinical, laboratory and radiological outcomes after 6 months. These preliminary results support the use of gentamicin-coated implants as a new potential treatment option for the prevention of infection in trauma patients and in revision cases. Level of Evidence Level II.
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              Evidence-Based Recommendations for Local Antimicrobial Strategies and Dead Space Management in Fracture-Related Infection

              Summary: Fracture-related infection (FRI) remains a challenging complication that imposes a heavy burden on orthopaedic trauma patients. The surgical management eradicates the local infectious focus and if necessary facilitates bone healing. Treatment success is associated with debridement of all dead and poorly vascularized tissue. However, debridement is often associated with the formation of a dead space, which provides an ideal environment for bacteria and is a potential site for recurrent infection. Dead space management is therefore of critical importance. For this reason, the use of locally delivered antimicrobials has gained attention not only for local antimicrobial activity but also for dead space management. Local antimicrobial therapy has been widely studied in periprosthetic joint infection, without addressing the specific problems of FRI. Furthermore, the literature presents a wide array of methods and guidelines with respect to the use of local antimicrobials. The present review describes the scientific evidence related to dead space management with a focus on the currently available local antimicrobial strategies in the management of FRI. Level of Evidence: Therapeutic Level V. See Instructions for Authors for a complete description of levels of evidence.
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                Author and article information

                Journal
                SICOT J
                SICOT J
                sicotj
                SICOT-J
                EDP Sciences
                2426-8887
                2021
                31 December 2021
                : 7
                : ( publisher-idID: sicotj/2021/01 )
                : 66
                Affiliations
                [1 ] Limb Reconstruction, Division of Orthopaedic Surgery, Faculty of Medicine and Health Sciences, Stellenbosch University 7600 Stellenbosch Cape Town South Africa
                [2 ] University of California, San Francisco, Limb Lengthening & Reconstruction Center, UCSF Benioff Children’s Hospital Oakland 747 52nd Street, OPC 1st Floor Oakland CA 94609 USA
                [3 ] Benha University Hospital 13511 Benha Egypt
                [4 ] Hull Limb Reconstruction and Bone Infection Unit, Hull University Teaching Hospitals, University of Hull Hull HU3 2JZ United Kingdom
                [5 ] Paediatric Orthopaedics, B. Nanavati Super Specialty Hospital 400056 Mumbai India
                [6 ] Thangam Institute of Orthopaedic Surgery, Trauma & Ilizarov, Thangam Hospital Palakkad 678004 Kerala India
                [7 ] Bone reconstruction and lengthening sector, El Cruce High Complexity Hospital 1888 Buenos Aires Argentina
                [8 ] Center for Limb Lengthening & Reconstruction, Mangal Anand Hospital 400071 Mumbai India
                [9 ] Royal Liverpool University Hospitals and Royal Liverpool Children’s Hospital L7 8XP Liverpool United Kingdom
                [10 ] The James Cook University Hospital TS4 3BW Middlesbrough United Kingdom
                [11 ] Children’s Orthopaedics and Reconstruction, Aarhus University Hospital Palle Juul-Jensens Boulevard 99, J801 8200 Aarhus Denmark
                Author notes
                Author information
                http://orcid.org/0000-0002-0567-3373
                http://orcid.org/0000-0003-3779-1419
                http://orcid.org/0000-0002-9803-2582
                http://orcid.org/0000-0003-3781-1651
                http://orcid.org/0000-0001-6227-5841
                http://orcid.org/0000-0002-3820-9745
                http://orcid.org/0000-0002-7234-4350
                http://orcid.org/0000-0001-7934-2983
                Article
                sicotj210108 10.1051/sicotj/2021066
                10.1051/sicotj/2021066
                8725545
                34981739
                5fb61f23-a741-4f15-ad45-c9ba0218c8d7
                © The Authors, published by EDP Sciences, 2021

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 23 November 2021
                : 13 December 2021
                Page count
                Figures: 4, Tables: 0, Equations: 0, References: 54, Pages: 9
                Categories
                Review Article
                Lower Limb

                limb reconstruction,limb lengthening,limb salvage,bone transport,external fixation,ilizarov,resource-limited environments,low- and middle-income countries

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