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      Post-translational modifications in the context of therapeutic proteins.

      1 ,
      Nature biotechnology
      Springer Science and Business Media LLC

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          Abstract

          The majority of protein-based biopharmaceuticals approved or in clinical trials bear some form of post-translational modification (PTM), which can profoundly affect protein properties relevant to their therapeutic application. Whereas glycosylation represents the most common modification, additional PTMs, including carboxylation, hydroxylation, sulfation and amidation, are characteristic of some products. The relationship between structure and function is understood for many PTMs but remains incomplete for others, particularly in the case of complex PTMs, such as glycosylation. A better understanding of such structural-functional relationships will facilitate the development of second-generation products displaying a PTM profile engineered to optimize therapeutic usefulness.

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          Author and article information

          Journal
          Nat Biotechnol
          Nature biotechnology
          Springer Science and Business Media LLC
          1087-0156
          1087-0156
          Oct 2006
          : 24
          : 10
          Affiliations
          [1 ] Industrial Biochemistry Program, University of Limerick, Castletroy, Limerick City, Ireland. Gary.walsh@ul.ie
          Article
          nbt1252
          10.1038/nbt1252
          17033665
          5f18d0aa-ce0d-4bb2-bc25-97aa7e6f8086
          History

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