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      Bibliometric analysis of scientific papers on extracellular vesicles in kidney disease published between 1999 and 2022

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          Abstract

          Background: In recent years, there has been an increasing interest in using extracellular vesicles (EVs) as potential therapeutic agents or natural drug delivery systems in kidney-related diseases. However, a detailed and targeted report on the current condition of extracellular vesicle research in kidney-related diseases is lacking. Therefore, this prospective study was designed to investigate the use of bibliometric analysis to comprehensively overview the current state of research and frontier trends on extracellular vesicle research in kidney-related diseases using visualization tools.

          Methods: The Web of Science Core Collection (WoSCC) database was searched to identify publications related to extracellular vesicle research in kidney-related diseases since 1999. Citespace, Microsoft Excel 2019, VOSviewer software, the R Bibliometrix Package, and an online platform were used to analyze related research trends to stratify the publication data and collaborations.

          Results: From 1 January 1999 to 26 June 2022, a total of 1,122 EV-related articles and reviews were published, and 6,486 authors from 1,432 institutions in 63 countries or regions investigated the role of extracellular vesicles in kidney-related diseases. We found that the number of articles on extracellular vesicles in kidney-related diseases increased every year. Dozens of publications were from China and the United States. China had the most number of related publications, in which the Southeast University (China) was the most active institution in all EV-related fields. Liu Bi-cheng published the most papers on extracellular vesicles, while Clotilde Théry had the most number of co-citations. Most papers were published by The International Journal of Molecular Sciences, while Kidney International was the most co-cited journal for extracellular vesicles. We found that exosome-related keywords included exosome, exosm, expression, extracellular vesicle, microRNA, microvesicle, and liquid biopsy, while disease- and pathological-related keywords included biomarker, microRNA, apoptosis, mechanism, systemic lupus erythematosus, EGFR, acute kidney injury, and chronic kidney disease. Acute kidney disease (AKI), CKD, SLE, exosome, liquid biopsy, and extracellular vesicle were the hotspot in extracellular vesicle and kidney-related diseases research.

          Conclusion: The field of extracellular vesicles in kidney-related disease research is rapidly growing, and its domain is likely to expand in the next decade. The findings from this comprehensive analysis of extracellular vesicles in kidney-related disease research could help investigators to set new diagnostic, therapeutic, and prognostic ideas or methods in kidney-related diseases.

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          Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

          Clotilde Théry, Kenneth W Witwer, Elena Aikawa … (2020)
          ABSTRACT The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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            Software survey: VOSviewer, a computer program for bibliometric mapping

            Nees Jan van Eck, Ludo Waltman (2011)
            We present VOSviewer, a freely available computer program that we have developed for constructing and viewing bibliometric maps. Unlike most computer programs that are used for bibliometric mapping, VOSviewer pays special attention to the graphical representation of bibliometric maps. The functionality of VOSviewer is especially useful for displaying large bibliometric maps in an easy-to-interpret way. The paper consists of three parts. In the first part, an overview of VOSviewer’s functionality for displaying bibliometric maps is provided. In the second part, the technical implementation of specific parts of the program is discussed. Finally, in the third part, VOSviewer’s ability to handle large maps is demonstrated by using the program to construct and display a co-citation map of 5,000 major scientific journals.
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              The biology, function, and biomedical applications of exosomes

              Raghu Kalluri, Valerie LeBleu (2020)
              The study of extracellular vesicles (EVs) has the potential to identify unknown cellular and molecular mechanisms in intercellular communication and in organ homeostasis and disease. Exosomes, with an average diameter of ~100 nanometers, are a subset of EVs. The biogenesis of exosomes involves their origin in endosomes, and subsequent interactions with other intracellular vesicles and organelles generate the final content of the exosomes. Their diverse constituents include nucleic acids, proteins, lipids, amino acids, and metabolites, which can reflect their cell of origin. In various diseases, exosomes offer a window into altered cellular or tissue states, and their detection in biological fluids potentially offers a multicomponent diagnostic readout. The efficient exchange of cellular components through exosomes can inform their applied use in designing exosome-based therapeutics.
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                Author and article information

                Contributors
                Journal
                Journal ID (nlm-ta): Front Cell Dev Biol
                Journal ID (iso-abbrev): Front Cell Dev Biol
                Journal ID (publisher-id): Front. Cell Dev. Biol.
                Title: Frontiers in Cell and Developmental Biology
                Publisher: Frontiers Media S.A.
                ISSN (Electronic): 2296-634X
                Publication date (Electronic): 05 January 2023
                Publication date Collection: 2022
                Volume: 10
                Electronic Location Identifier: 1070516
                Affiliations
                [1] 1 Department of Pediatrics , The Third Xiangya Hospital , Central South University , Changsha, China
                [2] 2 Department of Ophthalmology , The Second Xiangya Hospital , Central South University , Changsha, China
                [3] 3 Department of General Surgery , Xiangya Hospital , Central South University , Changsha, China
                Author notes

                Edited by: Yang-Mooi Lim, Universiti Tunku Abdul Rahman, Malaysia

                Reviewed by: Giulia Cricrì, University of Milan, Italy

                Alexander N. Kapustin, AstraZeneca, United Kingdom

                *Correspondence: Mingyi Zhao, zhao_mingyi@ 123456csu.edu.cn ; Qingnan He, heqn2629@ 123456csu.edu.cn

                This article was submitted to Stem Cell Research, a section of the journal Frontiers in Cell and Developmental Biology

                Article
                Publisher ID: 1070516
                DOI: 10.3389/fcell.2022.1070516
                PMC ID: 9849820
                PubMed ID: 36684427
                SO-VID: 5f107037-38ad-4b80-9b74-bb32abfe6919
                Copyright © Copyright © 2023 Hun, Wen, Han, Vun, Zhao and He.
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                Date received : 14 October 2022
                Date accepted : 09 December 2022
                Categories
                Subject: Cell and Developmental Biology
                Subject: Original Research

                Keywords: kidney disease,evs,exosomes,acute kidney disease,chronic kidney disease,bibliometric analysis
                Data availability:
                Keywords: kidney disease, evs, exosomes, acute kidney disease, chronic kidney disease, bibliometric analysis

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