Clinical spectrum and therapeutic management of systemic lupus erythematosus-associated macrophage activation syndrome: A study of 103 episodes in 89 adult patients.

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Abstract

Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory syndrome that can occur during systemic lupus erythematosus (SLE). Data on MAS in adult SLE patients are very limited. The aim of this study is to describe the clinical characteristics, laboratory findings, treatments, and outcomes of a large series of SLE-associated MAS.

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Author and article information

Journal

Journal ID (iso-abbrev): Autoimmun Rev

Title: Autoimmunity reviews

Publisher: Elsevier BV

ISSN (Electronic): 1873-0183

ISSN (Print): 1568-9972

Publication date (Electronic): May 05 2017

Affiliations

[1 ] Service d'immunologie Clinique et médecine interne, CHU de Strasbourg. Electronic address: pierre-edouard.gavand@chru-strasbourg.fr.

[2 ] Division of Internal Medicine, Department of Medical & Surgical Sciences, University of Bologna, S Orsola-Malpighi Hospital, Bologna, Italy.

[3 ] Service de rhumatologie, CHU Strasbourg.

[4 ] Service de médecine interne, hôpital Cochin.

[5 ] Service de médecine interne et d'immunologie clinique, CHU Conception Marseille - APHM.

[6 ] Service de médecine interne CHU Bichat, Paris. Université paris VII.

[7 ] Service de médecine interne, CH Mulhouse.

[8 ] Service de médecine interne, hôpital Cochin, Centre de Référence pour les vascularites nécrosantes et la sclérodermie systémique, DHU Authors (Autoimmune and Hormonal Diseases), Université Paris Descartes, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.

[9 ] Service d'immunologie Clinique et médecine interne, CHU de Strasbourg.

[10 ] Service de médecine interne, CHU Amiens.

[11 ] Service de médecine Interne et Immunologie Clinique, HP Metz Site Belle Isle.

[12 ] Service de médecine interne, CHU Besançon.

[13 ] CHU de Nancy, Internal Medicine and Clinical immunology department.

[14 ] Service de médecine interne, CHU Nantes.

[15 ] Service de médecine interne, CHU Reims.

[16 ] Service de médecine interne, CHU Fort-de-, France.

[17 ] Service de médecine Interne - Groupe Hospitalier Diaconesses- Croix Saint-Simon, Paris.

[18 ] CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000, Lille, France.

[19 ] Service de médecine interne 2, groupement hospitalier La Pitié-Salpétrière, Paris.

[20 ] URC CRC Hopital Avicenne, Bobigny, France.

[21 ] Service de médecine interne, CHU Avicennes, Bobigny, France.

Article

Publisher Item ID: S1568-9972(17)30130-1

DOI: 10.1016/j.autrev.2017.05.010

PubMed ID: 28483541

SO-VID: 5ea1800e-b46c-4910-9324-558360abe1b3

History

Keywords: Macrophage activation syndrome,systemic lupus erythematosus

Data availability:

Keywords: Macrophage activation syndrome, systemic lupus erythematosus

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