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      Mesenchymal Stem Cell Senescence during Aging:From Mechanisms to Rejuvenation Strategies

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          Abstract

          In cell transplantation therapy, mesenchymal stem cells(MSCs)are ideal seed cells due to their easy acquisition and cultivation, strong regenerative capacity, multi-directional differentiation abilities, and immunomodulatory effects. Autologous MSCs are better applicable compared with allogeneic MSCs in clinical practice. The elderly are the main population for cell transplantation therapy, but as donor aging, MSCs in the tissue show aging-related changes. When the number of generations of in vitro expansion is increased, MSCs will also exhibit replicative senescence. The quantity and quality of MSCs decline during aging, which limits the efficacy of autologous MSCs transplantation therapy. In this review, we examine the changes in MSC senescence as a result of aging, discuss the progress of research on mechanisms and signalling pathways of MSC senescence, and discuss possible rejuvenation strategies of aged MSCs to combat senescence and enhance the health and therapeutic potential of MSCs.

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          Multilineage potential of adult human mesenchymal stem cells.

          M. Pittenger, A M Mackay, S C Beck … (1999)
          Human mesenchymal stem cells are thought to be multipotent cells, which are present in adult marrow, that can replicate as undifferentiated cells and that have the potential to differentiate to lineages of mesenchymal tissues, including bone, cartilage, fat, tendon, muscle, and marrow stroma. Cells that have the characteristics of human mesenchymal stem cells were isolated from marrow aspirates of volunteer donors. These cells displayed a stable phenotype and remained as a monolayer in vitro. These adult stem cells could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages. Individual stem cells were identified that, when expanded to colonies, retained their multilineage potential.
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            Designing hydrogels for controlled drug delivery

            David Mooney, Jianyu Li (2016)
            Hydrogel delivery systems can leverage therapeutically beneficial outcomes of drug delivery and have found clinical use. Hydrogels can provide spatial and temporal control over the release of various therapeutic agents, including small-molecule drugs, macromolecular drugs and cells. Owing to their tunable physical properties, controllable degradability and capability to protect labile drugs from degradation, hydrogels serve as a platform in which various physiochemical interactions with the encapsulated drugs control their release. In this Review, we cover multiscale mechanisms underlying the design of hydrogel drug delivery systems, focusing on physical and chemical properties of the hydrogel network and the hydrogel-drug interactions across the network, mesh, and molecular (or atomistic) scales. We discuss how different mechanisms interact and can be integrated to exert fine control in time and space over the drug presentation. We also collect experimental release data from the literature, review clinical translation to date of these systems, and present quantitative comparisons between different systems to provide guidelines for the rational design of hydrogel delivery systems.
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              The serial cultivation of human diploid cell strains.

              L Hayflick, P.S. Moorhead (1961)
              Article 0 comments Cited 853 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Aging Dis
                Journal ID (iso-abbrev): Aging Dis
                Title: Aging and Disease
                Publisher: JKL International LLC
                ISSN (Electronic): 2152-5250
                Publication date Collection: 1 October 2023
                Publication date (Electronic): 1 October 2023
                Volume: 14
                Issue: 5
                Pages: 1651-1676
                Affiliations
                [1-AD-14-5-1651] 1The National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha, China.
                [2-AD-14-5-1651] 2Hunan provincical key laboratory of Neurorestoratology, the Second Affiliated Hospital, Hunan Normal University, Changsha, China.
                [3-AD-14-5-1651] 3Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, 410011, China, Changsha
                Author notes
                [* ]Correspondence should be addressed to: Dr. Lite Ge, Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, China. E-mail: gelite@ 123456csu.edu.cn. Dr. Ming Lu, Department of Neurosurgery, the Second Affiliated Hospital of Hunan Normal University, Changsha, China. mail: lumingcs163@ 123456163.com.
                [#]

                These authors contributed equally to this work.

                Article
                Publisher ID: ad-14-5-1651
                DOI: 10.14336/AD.2023.0208
                PMC ID: 10529739
                PubMed ID: 37196126
                SO-VID: 5e5cb7f2-cb29-45b2-a45c-5862eba5ff79
                Copyright © copyright: © 2023 Jiang et al.
                License:

                this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

                History
                Date received : 14 November 2022
                Date revision requested : 4 February 2023
                Date accepted : 8 February 2023
                Categories
                Subject: Review

                Keywords: mesenchymal stem cells,aging,cell transplantation therapy,cell senescence,rejuvenation strategy,autologous mscs transplantation
                Data availability:
                Keywords: mesenchymal stem cells, aging, cell transplantation therapy, cell senescence, rejuvenation strategy, autologous mscs transplantation

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