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      Leclercia adecarboxylata, a rare cause of soft tissue infections in immunocompromised patients, case report and review of the literature Translated title: Leclercia adecarboxylata, una causa rara de infección de tejidos blandos en pacientes inmunocomprometidos, reporte de caso y revisión de la literatura

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          Abstract

          Abstract Leclercia adecarboxylata is a member of the Enterobacteriaceae family that has been isolated from several environmental and animal specimens, however it rarely causes diseases in human beings. It has natural resistance to several antibiotics, and has shown the ability to harbor and produce enzymes capable of hydrolyzing most of the antibiotics used in daily clinical practice, making its treatment a challenge when a strain with such characteristics causes disease. Here we report the first known case of infection by Leclercia adecarboxylata after a trauma with plant material, in a 69-year-old male patient, with poorly controlled Diabetes Mellitus type 2.

          Translated abstract

          Resumen Leclercia adecarboxylata es un miembro de la familia Enterobacteriaceae que ha sido aislada tanto de muestras de animales como medioambientales, sin embargo raramente produce enfermedad en seres humanos. Tiene resistencia natural a varios antibióticos y se ha encontrado que tiene enzimas capaces de hidrolizar la mayoría de los antibióticos utilizados en la práctica clínica, lo cual hace un verdadero tratar una infección por este microorganismo en humanos. Aquí reportamos el primer caso de infección por Leclercia adecarboxylata luego de un trauma con material vegetal, en un paciente de 69 años y con una diabetes tipo 2, mal controlada.

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          Most cited references14

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          Production of plasmid-encoding NDM-1 in clinical Raoultella ornithinolytica and Leclercia adecarboxylata from China

          Raoultella ornithinolytica YNKP001 and Leclercia adecarboxylata P10164, which harbor conjugative plasmids pYNKP001-NDM and pP10164-NDM, respectively, were isolated from two different Chinese patients, and their complete nucleotide sequences were determined. Production of NDM-1 enzyme by these plasmids accounts for the carbapenem resistance of these two strains. This is the first report of bla NDM in L. adecarboxylata and third report of this gene in R. ornithinolytica. pYNKP001-NDM is very similar to the IncN2 NDM-1-encoding plasmids pTR3, pNDM-ECS01, and p271A, whereas pP10164-NDM is similar to the IncFIIY bla NDM-1-carrying plasmid pKOX_NDM1. The bla NDM-1 genes of pYNKP001-NDM and pP10164-NDM are embedded in Tn125-like elements, which represent two distinct truncated versions of the NDM-1-encoding Tn125 prototype observed in pNDM-BJ01. Flanking of these two Tn125-like elements by miniature inverted repeat element (MITE) or its remnant indicates that MITE facilitates transposition and mobilization of bla NDM-1 gene contexts.
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            Is Leclercia adecarboxylata a new and unfamiliar marine pathogen?

            Leclercia adecarboxylata infection is rarely reported in the context of human infections. In the scant cases reported in the literature, it usually involves individuals who are immunocompromised with infections of a polymicrobial nature. Recently, data have begun to accumulate suggesting that L. adecarboxylata is a pathogen associated with water environments. We review the literature regarding L. adecarboxylata infections and present a case of cellulitis and soft-tissue infection in the foot of a healthy surfer.
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              Leclercia Adecarboxylata Isolation: Case Reports and Review

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                inf
                Infectio
                Infect.
                Asociación Colombiana de Infectología. (Bogotá, Distrito Capital, Colombia )
                0123-9392
                December 2018
                : 22
                : 4
                : 223-226
                Affiliations
                [2] Bogotá Bogotá orgnameUniversidad Militar Nueva Granada orgdiv1School of Medicine Colombia
                [5] Bogotá orgnameHospital Militar Central orgdiv1Internal Medicine Department Colombia
                [6] Bogotá orgnameHospital Militar Central orgdiv1Clinical Laboratory, Microbiology section Colombia
                [4] Bogotá orgnameHospital Militar Central orgdiv1Infectious Diseases Department Colombia
                [1] orgnameHospital Militar Central "GREINMIL" orgdiv1Grupo de Investigación en Enfermedades Infecciosas Colombia
                [3] Bogotá orgnameClínica de la Mujer orgdiv1Infectious Diseases Department Colombia
                Article
                S0123-93922018000400223
                10.22354/in.v22i4.741
                5c518d6f-05b1-47b4-9905-e903d4d4eaa8

                This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

                History
                : 02 February 2017
                : 07 May 2018
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 16, Pages: 4
                Product

                SciELO Colombia


                Leclercia adecarboxylata,infecciones de los tejidos blandos,Bacilos y Cocos Aerobios Gramnegativos,adecarboxylata,Gram-Negative Aerobic Rods and Cocci,soft tissue infections

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