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      Super-pulsed Diode Laser in the Therapy of Inferior Alveolar Nerve Paresthesia After Mandibular Third Molar Extraction: A Case Report

      case-report
      1 , 2 , , 3 , 4
      ,
      Cureus
      Cureus
      injured inferior alveolar nerve, oral paresthesia, oral surgery, photobiomodulation, super-pulsed laser

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          Abstract

          Oral paresthesia occurs when one of the nerves in the region is injured, usually the inferior alveolar and/or lingual nerve, after dental procedures such as the extraction of lower third molars. The objective of this study was to describe the case of a patient who received photobiomodulation (PBM) therapy for paresthesia of the inferior alveolar nerve (IAN) caused by the extraction of mandibular third molars. The protocol used involved a super-pulsed diode laser with dual wavelengths of 810 nm and 980 nm, 1 W, 60 seconds, 12.15 J/cm², with a spot size of 25 mm in the extraoral area. In the intraoral region, 0.3 W, 60 seconds, 46.77 J/cm², with a 7 mm tip, was applied. Before starting each PBM session, mapping of the area was performed to delineate the regions with paresthesia, and the degree of sensitivity was evaluated using a visual analog scale (VAS). On the first day, before the first laser therapy session, the VAS assessment was 7, indicating partial loss of sensitivity. After 48 hours and before the second PBM session, the patient reported a slight tingling sensation and substantial improvement in chin sensitivity, with a VAS score of 4.5. After nine sessions, the patient reported recovery of sensitivity in all affected regions (VAS = 0), with positive and normal responses to touch with a dental explorer. Within the parameters established for this clinical case, our results suggest that PBM therapy may improve the loss of sensation observed in IAN paresthesia following injury or surgical trauma.

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          Most cited references17

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          Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy.

          Photobiomodulation (PBM) also known as low-level laser (or light) therapy (LLLT), has been known for almost 50 years but still has not gained widespread acceptance, largely due to uncertainty about the molecular, cellular, and tissular mechanisms of action. However, in recent years, much knowledge has been gained in this area, which will be summarized in this review. One of the most important chromophores is cytochrome c oxidase (unit IV in the mitochondrial respiratory chain), which contains both heme and copper centers and absorbs light into the near-infra-red region. The leading hypothesis is that the photons dissociate inhibitory nitric oxide from the enzyme, leading to an increase in electron transport, mitochondrial membrane potential and ATP production. Another hypothesis concerns light-sensitive ion channels that can be activated allowing calcium to enter the cell. After the initial photon absorption events, numerous signaling pathways are activated via reactive oxygen species, cyclic AMP, NO and Ca2+, leading to activation of transcription factors. These transcription factors can lead to increased expression of genes related to protein synthesis, cell migration and proliferation, anti-inflammatory signaling, anti-apoptotic proteins, antioxidant enzymes. Stem cells and progenitor cells appear to be particularly susceptible to LLLT.
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            Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation

            Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential. Another mechanism involves activation of light or heat-gated ion channels. This review will cover the redox signaling that occurs in PBM and examine the difference between healthy and stressed cells, where PBM can have apparently opposite effects. PBM has a marked effect on stem cells, and this is proposed to operate via mitochondrial redox signaling. PBM can act as a pre-conditioning regimen, and can interact with exercise on muscles. Photobiomodulation uses red or NIR light to stimulate healing and regeneration in tissue. The primary chromophores are cytochrome c oxidase in mitochondria and light/heat gated ion channels. Both mechanisms lead to generation of reactive oxygen species that can activate transcription factors and may act as an exercise mimetic.
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              Review of light parameters and photobiomodulation efficacy: dive into complexity

              Abstract. Photobiomodulation (PBM) therapy, previously known as low-level laser therapy, was discovered more than 50 years ago, yet there is still no agreement on the parameters and protocols for its clinical application. Some groups have recommended the use of a power density less than 100    mW / cm 2 and an energy density of 4 to 10    J / cm 2 at the level of the target tissue. Others recommend as much as 50    J / cm 2 at the tissue surface. The wide range of parameters that can be applied (wavelength, energy, fluence, power, irradiance, pulse mode, treatment duration, and repetition) in some cases has led to contradictory results. In our review, we attempt to evaluate the range of effective and ineffective parameters in PBM. Studies in vitro with cultured cells or in vivo with different tissues were divided into those with higher numbers of mitochondria (muscle, brain, heart, nerve) or lower numbers of mitochondria (skin, tendon, cartilage). Graphs were plotted of energy density against power density. Although the results showed a high degree of variability, cells/tissues with high numbers of mitochondria tended to respond to lower doses of light than those with lower number of mitochondria. Ineffective studies in cells with high mitochondrial activity appeared to be more often due to over-dosing than to under-dosing.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                21 December 2024
                December 2024
                : 16
                : 12
                : e76147
                Affiliations
                [1 ] Patologia Bucal y Cirugia Maxilofacial, Hospital Jose Gregorio Hernandez, Caracas, VEN
                [2 ] Oral Medicine, IPD Institute, Caracas, VEN
                [3 ] Oral Medicine, Almón Brito IPD (Implantology, Periodontology, Oral Diagnostic) Institute, Caracas, VEN
                [4 ] Implantology and Periodontology, Almón Brito IPD (Implantology, Periodontology, Oral Diagnostic) Institute, Caracas, VEN
                Author notes
                Article
                10.7759/cureus.76147
                11745489
                39835038
                5c37ee77-4a03-4c08-b3f3-43a9d22734ce
                Copyright © 2024, Brito et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0., which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 17 December 2024
                Categories
                Dentistry
                Oral Medicine

                injured inferior alveolar nerve,oral paresthesia,oral surgery,photobiomodulation,super-pulsed laser

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