入选2019年3月–2021年3月就诊于新疆医科大学第一附属医院心脏中心的接受冠状动脉造影检查的患者130例。利用稳定同位素液相色谱/质谱法测定患者血浆中TMAO的水平。分析血浆TMAO水平和三酰甘油(triglycerides, TG)、总胆固醇(total cholesterol, TC)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-c)和低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-c)等血脂水平的相关性。
To investigate the correlation between the plasma levels of trimethylamine N-oxide (TMAO) and lipid levels in hyperlipidemic patients.
A total of 130 patients who received treatment and underwent coronary angiography at the Heart Center, the First Affiliated Hospital of Xinjiang Medical University between March 2019 and March 2021 were enrolled. Patients' plasma TMAO levels were determined by stable isotope liquid chromatography/mass spectrometry. The correlation between plasma TMAO levels and the levels of lipids, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), was analyzed.
Patients with hyperlipidemia had higher plasma TMAO levels (μmol/L) than patients without hyperlipidemia did (6.73±5.40 vs. 3.82±2.65), with the difference being statistically significant ( P<0.05). After controlling for the effects of age and body mass index, partial correlation analysis revealed that plasma TMAO levels were positively correlated with plasma TG ( r=0.286, P<0.001) and negatively correlated with HDL-C ( r=−0.366, P<0.001).