For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
8
views
57
references
 Top references
cited by
4
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      711
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Relationship between Antifungal Activity against Candida albicans and Electron Parameters of Selected N-Heterocyclic Thioamides

      research-article

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Due to the increasing demand for new pharmaceuticals showing biological activity against pathogenic microorganisms, there is increasing search for new compounds with predicted biological activity. Variously substituted thioamide derivatives with 1.3 and 1.2 ring of thiazole and 1,3,4-thiadiazole, as well as pyrazole were assessed for their activity against Candida albicans. Activity of majority of tested thioamides was larger as compared with that of the reference drugs. The electron parameters of obtained N-heterocyclic thioamides were determined and dependencies on their biological activity against Candida albicans were studied. The best electron compliance of produced bindings with the activity against Candida albicans was observed for the derivatives containing 1,3,4-thiadiazole ring.

          Related collections

          Most cited references57

          • Record: found
          • Abstract: not found
          • Article: not found

          Absolute electronegativity and hardness: application to inorganic chemistry

          Ralph G. Pearson (1988)
          Article 0 comments Cited 475 times – based on 0 reviews     Review now
          Article has an altmetric score of 9
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Absolute electronegativity and hardness correlated with molecular orbital theory.

            R G Pearson (1986)
            The concepts of absolute electronegativity, chi, and absolute hardness, eta, are incorporated into molecular orbital theory. A graphic and concise definition of hardness is given as twice the energy gap between the highest occupied molecular orbital and the lowest unoccupied molecular orbital. Useful correlations can now be made between chemical behavior, visible-UV absorption spectra, optical polarizability, ionization potentials, and electron affinities.
            Article 0 comments Cited 241 times – based on 0 reviews     Review now
            Article has an altmetric score of 3
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. National Nosocomial Infections Surveillance System.

              C Beck-Sague, W Jarvis (1993)
              To identify pathogens causing nosocomial fungal infections and the secular trend in their incidence in US hospitals, data from the National Nosocomial Infections Surveillance System, 1980-1990, were analyzed. During that period, 30,477 fungal infections were reported. The rate rose from 2.0 to 3.8 infections/1000 discharges. The highest number of nosocomial fungal infections/1000 discharges was reported from the burn/trauma service (16.1). Candida albicans was the most frequently isolated fungal pathogen (59.7%), followed by other Candida species (18.6%). The rate increased at all four major anatomic sites of infection. Patients with bloodstream infections who had a central intravascular catheter were more likely to have a fungal pathogen isolated than were other patients with bloodstream infection (relative risk = 3.2; P < .001): 29% of fungemia patients and 17% of patients with bloodstream infection due to other pathogens died during hospitalization (P < .001). Fungi are emerging as important nosocomial pathogens and control efforts should target fungal infections, especially fungemia.
              Article 0 comments Cited 64 times – based on 0 reviews     Review now
              Article has an altmetric score of 6
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): Indian J Pharm Sci
                Journal ID (iso-abbrev): Indian J Pharm Sci
                Journal ID (publisher-id): IJPhS
                Title: Indian Journal of Pharmaceutical Sciences
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 0250-474X
                ISSN (Electronic): 1998-3743
                Publication date (Print): Jul-Aug 2014
                Volume: 76
                Issue: 4
                Pages: 287-298
                Affiliations
                [1]University of Life Sciences in Lublin, Department of Chemistry, 15 Akademicka Street, 20-950 Lublin, Poland
                [1 ]Medical University of Bialystok, Department of General Nursing, Bialystok, Poland
                Author notes
                [* ] Address for correspondence E-mail: jadwiga.stachowicz@ 123456up.lublin.pl
                Article
                Publisher ID: IJPhS-76-287
                PMC ID: 4171865
                PubMed ID: 25284926
                SO-VID: 5bdf2c78-4a38-4fbf-a8f4-38e8588b6cda
                Copyright © Copyright: © Indian Journal of Pharmaceutical Sciences
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 10 June 2013
                Date revision received : 25 April 2014
                Date accepted : 03 May 2014
                Categories
                Subject: Research Paper

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: thioamides,antifungal activity,candida albicans,electron parameters
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: thioamides, antifungal activity, candida albicans, electron parameters

                Comments

                Comment on this article

                Similar content711

                See all similar

                Cited by4

                See all cited by

                Most referenced authors301

                See all reference authors