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Assessment of a New ROS1 Immunohistochemistry Clone (SP384) for the Identification of ROS1 Rearrangements in Non-Small Cell Lung Carcinoma Patients: the ROSING Study
Esther Conde ,
Susana Hernandez ,
Rebeca Martinez ,
Barbara Angulo ,
Javier De Castro ,
Ana Collazo-Lorduy ,
Beatriz Jimenez ,
Alfonso Muriel ,
Jose Luis Mate ,
Teresa Moran ,
Ignacio Aranda ,
Bartomeu Massuti ,
Federico Rojo ,
Manuel Domine ,
Irene Sansano ,
Felip Garcia ,
Enriqueta Felip ,
Nuria Mancheño ,
Oscar Juan ,
Julian Sanz ,
Jose Luis Gonzalez-Larriba ,
Lidia Atienza-Cuevas ,
Esperanza Arriola-Arellano ,
Ihab Abdulkader ,
Jorge Garcia-Gonzalez ,
Carmen Camacho ,
Delvys Rodriguez-Abreu ,
Cristina Teixido ,
Noemi Reguart ,
Ana Gonzalez-Piñeiro ,
Martin Lazaro-Quintela ,
Maria Dolores Lozano ,
Alfonso Gurpide ,
Javier Gomez-Roman ,
Marta Lopez-Brea ,
Lara Pijuan ,
Marta Salido ,
Edurne Arriola ,
Amparo Company ,
Amelia Insa ,
Isabel Esteban-Rodriguez ,
Monica Saiz ,
Eider Azkona ,
Ramiro Alvarez ,
Angel Artal ,
Maria Luz Plaza ,
David Aguiar ,
Ana Belen Enguita ,
Amparo Benito ,
Luis Paz-Ares ,
Pilar Garrido ,
Fernando Lopez-Rios
July 2019
July 2019
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Abstract
The ROS1 gene rearrangement has become an important biomarker in NSCLC. The College
of American Pathologists/International Association for the Study of Lung Cancer/Association
for Molecular Pathology testing guidelines support the use of ROS1 immunohistochemistry
(IHC) as a screening test, followed by confirmation with fluorescence in situ hybridization
(FISH) or a molecular test in all positive results. We have evaluated a novel anti-ROS1
IHC antibody (SP384) in a large multicenter series to obtain real-world data.