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      Polymorphism in the microglial cell-mobilizing CX3CR1 gene is associated with survival in patients with glioblastoma.

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      Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology
      Keywords: Adolescent, Adult, Aged, Female, Genotype, Glioblastoma, genetics, mortality, Humans, Immunohistochemistry, Male, Microglia, cytology, Middle Aged, Polymorphism, Genetic, Prospective Studies, Receptors, Chemokine, Retrospective Studies

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          Abstract

          Few reliable prognostic molecular markers have been characterized for glioblastoma multiforme (GBM), considered the deadliest of human cancers. We hypothesized that genetic polymorphisms in chemokines and their receptors, which together control microglial cell mobilization, may influence survival. Distributions of one polymorphism of the chemokine CCL2 (-2518A

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          PubMed ID:: 19001328
          DOI:: 10.1200/JCO.2008.17.2833

          ScienceOpen disciplines: Chemistry
          Keywords: Adolescent,Adult,Aged,Female,Genotype,Glioblastoma,genetics,mortality,Humans,Immunohistochemistry,Male,Microglia,cytology,Middle Aged,Polymorphism, Genetic,Prospective Studies,Receptors, Chemokine,Retrospective Studies
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          ScienceOpen disciplines: Chemistry
          Keywords: Adolescent, Adult, Aged, Female, Genotype, Glioblastoma, genetics, mortality, Humans, Immunohistochemistry, Male, Microglia, cytology, Middle Aged, Polymorphism, Genetic, Prospective Studies, Receptors, Chemokine, Retrospective Studies

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