Oxidative stress and male infertility

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Abstract

Background

Between 30% and 80% of patients with male infertility produce excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male infertility is unexplained in approximately half of cases. The strong connection between oxidative stress (OS) and male infertility has led recent investigators to propose the term “Male Oxidative Stress Infertility (MOSI)” to describe OS‐associated male infertility.

Methods

We searched the PubMed database for original and review articles to survey the effects of OS on male infertility, and then verified the effects and treatments.

Main findings

Seminal plasma contains many antioxidants that protect sperm from ROS, because low amounts of ROS are required in the physiological fertilization process. The production of excessive ROS causes OS which can lower fertility through lipid peroxidation, sperm DNA damage, and apoptosis. Several assays are available for evaluating OS, including the MiOXSYS® analyzer to measure oxidation‐reduction potential. Several measures should be considered for minimizing OS and improving clinical outcomes.

Conclusion

Accurately diagnosing patients with MOSI and identifying highly sensitive biomarkers through proteomics technology is vital for better clinical outcomes.

Abstract

Excessive ROS levels lead to OS which can reduce fertile capacity through lipid peroxidation of the membrane, sperm deoxyribonucleic acid fragmentation, and apoptosis

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Most cited references 139

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Role of oxidative stress in Alzheimer's disease

Wen-Juan Huang, Nai-xia Zhang, Wei-Wei Chen (2016)

Alzheimer's disease (AD) is the most common cause of disability in individuals aged >65 years worldwide. AD is characterized by the abnormal deposition of amyloid β (Aβ) peptide, and intracellular accumulation of neurofibrillary tangles of hyperphosphorylated τ protein and dementia. The neurotoxic oligomer Aβ peptide, which is the neuropathological diagnostic criterion of the disease, together with τ protein, are mediators of the neurodegeneration that is among the main causative factors. However, these phenomena are mainly initiated and enhanced by oxidative stress, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants. This imbalance can occur as a result of increased free radicals or a decrease in antioxidant defense, free radicals being a species that contains one or more unpaired electrons in its outer shell. The major source of potent free radicals is the reduction of molecular oxygen in water, that initially yields the superoxide radical, which produces hydrogen peroxide by the addition of an electron. The reduction of hydrogen peroxide produces highly reactive hydroxyl radicals, termed reactive oxygen species (ROS) that can react with lipids, proteins, nucleic acids, and other molecules and may also alter their structures and functions. Thus, tissues and organs, particularly the brain, a vulnerable organ, are affected by ROS due to its composition. The brain is largely composed of easily oxidizable lipids while featuring a high oxygen consumption rate. The current review examined the role of oxidative stress in AD.

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Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis.

Denny Sakkas, Juan G Alvarez (2010)

To review the mechanisms responsible for DNA fragmentation in human sperm, including those occurring during spermatogenesis and transport through the reproductive tract. The mechanisms examined include: apoptosis in the seminiferous tubule epithelium, defects in chromatin remodeling during the process of spermiogenesis, oxygen radical-induced DNA damage during sperm migration from the seminiferous tubules to the epididymis, the activation of sperm caspases and endonucleases, damage induced by chemotherapy and radiotherapy, and the effect of environmental toxicants. The different tests currently used for sperm DNA fragmentation analysis and the factors that determine the predictive value of sperm DNA fragmentation testing and their implications in the diagnosis and treatment of infertility are also discussed. Finally, we also scrutinize how the presence in the embryonic genome of DNA strand breaks or modifications of DNA nucleotides inherited from the paternal genome could impact the embryo and offspring. In particular we discuss how abnormal sperm could be dealt with by the oocyte and how sperm DNA abnormalities, which have not been satisfactorily repaired by the oocyte after fertilization, may interfere with normal embryo and fetal development. Sperm DNA can be modified through various mechanisms. The integrity of the paternal genome is therefore of paramount importance in the initiation and maintenance of a viable pregnancy both in a natural conception and in assisted reproduction. The need to diagnose sperm at a nuclear level is an area that needs further understanding so that we can improve treatment of the infertile couple. Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

Tian Tian, Ziling Wang, Jinhua Zhang (2017)

Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease whose incidence has risen worldwide in recent years. Accumulating evidence shows that oxidative stress plays an essential role in the pathogenesis and progression of IBD. This review highlights the generation of reactive oxygen species (ROS) and antioxidant defense mechanisms in the gastrointestinal (GI) tract, the involvement of oxidative stress signaling in the initiation and progression of IBD and its relationships with genetic susceptibility and the mucosal immune response. In addition, potential therapeutic strategies for IBD that target oxidative stress signaling are reviewed and discussed. Though substantial progress has been made in understanding the role of oxidative stress in IBD in humans and experimental animals, the underlying mechanisms are still not well defined. Thus, further studies are needed to validate how oxidative stress signaling is involved in and contributes to the development of IBD.

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Author and article information

Contributors

Teppei Takeshima:

ORCID: https://orcid.org/0000-0003-2733-5487

teppeitalia@gmail.com

Journal

Journal ID (nlm-ta): Reprod Med Biol

Journal ID (iso-abbrev): Reprod Med Biol

Journal ID (doi): 10.1111/(ISSN)1447-0578

Journal ID (publisher-id): RMB2

Title: Reproductive Medicine and Biology

Publisher: John Wiley and Sons Inc. (Hoboken )

ISSN (Print): 1445-5781

ISSN (Electronic): 1447-0578

Publication date (Electronic): 18 October 2020

Publication date Collection: January 2021

Volume: 20

Issue: 1 ( doiID: 10.1111/rmb2.v20.1 )

Pages: 41-52

Affiliations

[ ¹ ] Department of Urology, Reproduction Center Yokohama City University Medical Center Yokohama city Japan

Author notes

[*] [* ] Correspondence

Teppei Takeshima, Department of Urology, Reproduction Center, Yokohama City University Medical Center, Urafune‐Cho 4‐57, Minami‐ku, Yokohama city, Kanagawa, Japan.

Email: teppeitalia@ 123456gmail.com

Author information

Teppei Takeshima https://orcid.org/0000-0003-2733-5487

Shinnosuke Kuroda https://orcid.org/0000-0001-8890-0297

Yasushi Yumura https://orcid.org/0000-0003-0909-478X

Article

Publisher ID: RMB212353

DOI: 10.1002/rmb2.12353

PMC ID: 7812476

PubMed ID: 33488282

SO-VID: 5b8ab133-8974-432d-883f-290332c34cd7

License:

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

History

Date received : 18 April 2020

Date revision received : 19 September 2020

Date accepted : 28 September 2020

Page count

Figures: 3, Tables: 3, Pages: 12, Words: 9334

Funding

Funded by: JSPS KAKENHI

Award ID: 18K16739

Custom metadata

source-schema-version-number 2.0

cover-date January 2021

details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.6 mode:remove_FC converted:18.01.2021

Keywords: antioxidants,lipid peroxidation,male infertility,oxidative stress,reactive oxygen species

Data availability:

Keywords: antioxidants, lipid peroxidation, male infertility, oxidative stress, reactive oxygen species

Oxidative stress and male infertility

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Abstract

Background

Methods

Main findings

Conclusion

Abstract

Related collections

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Most cited references 139

Role of oxidative stress in Alzheimer's disease

Sperm DNA fragmentation: mechanisms of origin, impact on reproductive outcome, and analysis.

Pathomechanisms of Oxidative Stress in Inflammatory Bowel Disease and Potential Antioxidant Therapies

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