Vitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls

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Abstract

Dysbiosis is a common feature in the pathogenesis of inflammatory bowel diseases (IBD). Environmental factors, such as vitamin D deficiency, seem to play a role in the intestinal inflammation of IBD. The aim of this study was to investigate whether vitamin D administration has an impact on the bacterial composition in Crohn's disease (CD) compared to healthy controls (HC).

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Most cited references 33

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.

J Hugot, M Chamaillard, H Zouali … (2001)

Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's disease has been mapped to chromosome 16. Here we have used a positional-cloning strategy, based on linkage analysis followed by linkage disequilibrium mapping, to identify three independent associations for Crohn's disease: a frameshift variant and two missense variants of NOD2, encoding a member of the Apaf-1/Ced-4 superfamily of apoptosis regulators that is expressed in monocytes. These NOD2 variants alter the structure of either the leucine-rich repeat domain of the protein or the adjacent region. NOD2 activates nuclear factor NF-kB; this activating function is regulated by the carboxy-terminal leucine-rich repeat domain, which has an inhibitory role and also acts as an intracellular receptor for components of microbial pathogens. These observations suggest that the NOD2 gene product confers susceptibility to Crohn's disease by altering the recognition of these components and/or by over-activating NF-kB in monocytes, thus documenting a molecular model for the pathogenic mechanism of Crohn's disease that can now be further investigated.

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Inflammatory bowel disease.

Clara Abraham, Judy H Cho, Peter Moses (2010)

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Toward an Integrated Clinical, Molecular and Serological Classification of Inflammatory Bowel Disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology

Renzo Caprilli, Jean-Frédéric Colombel, Tariq Ahmad … (2005)

The discovery of a series of genetic and serological markers associated with disease susceptibility and phenotype in inflammatory bowel disease has led to the prospect of an integrated classification system involving clinical, serological and genetic parameters. The Working Party has reviewed current clinical classification systems in Crohn’s disease, ulcerative colitis and indeterminate colitis, and provided recommendations for clinical classification in practice. Progress with respect to integrating serological and genetic markers has been examined in detail, and the implications are discussed. While an integrated system is not proposed for clinical use at present, the introduction of a widely acceptable clinical subclassification is strongly advocated, which would allow detailed correlations among serotype, genotype and clinical phenotype to be examined and confirmed in independent cohorts of patients and, thereby, provide a vital foundation for future work.

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Author and article information

Journal

Title: Journal of Digestive Diseases

Abbreviated Title: Journal of Digestive Diseases

Publisher: Wiley

ISSN: 17512972

Publication date Created: April 2018

Publication date (Print): April 2018

Publication date (Electronic): April 27 2018

Volume: 19

Issue: 4

Pages: 225-234

Affiliations

[1 ]Division of Gastroenterology and Endocrinology, Department of Medicine II; Rostock University Medical Center; Rostock Germany

[2 ]Leibniz-Institut für Ostseeforschung Warnemünde (IOW); Biological Oceanography; Rostock Germany

[3 ]Estonian University of Life Sciences; Center of Limnology; Elva Estonia

[4 ]Institute of Medical Microbiology, Virology and Hygiene; University Medical Center; Rostock Germany

Article

DOI: 10.1111/1751-2980.12591

PubMed ID: 29573237

SO-VID: 5b2865d6-2938-4103-bde3-d6f6bcb968f8

License:

http://doi.wiley.com/10.1002/tdm_license_1.1

http://onlinelibrary.wiley.com/termsAndConditions#vor

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